ArticleCardiology research and practice2025
Intraprocedural Trigger Stratification via Protocolized Isoproterenol Provocation: A Mappability-Guided Strategy for Paroxysmal Atrial Fibrillation Ablation.
Article in Cardiology research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Beyond speed: why "skin-to-skin" time should not define quality in atrial fibrillation ablation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Review
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Authors and funding
9 authors.
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Abstract
Objective: To explore the feasibility of continuous low-dose isoproterenol (ISP) in identifying atrial fibrillation (AF) triggers under conscious sedation and to investigate the association between unmappable triggers and postablation recurrence. Methods: In 50 PAF patients (Group 1), standardized ISP infusion (2-4 μg/min) was administered to provoke triggers, followed by adenosine triphosphate (ATP) challenge (30-40 mg) if no arrhythmia was induced. A matched control cohort ( Results: In Group 1, provocative testing identified mappable triggers in 35 patients (Group 1A: 34 PV triggers and 10 non-PV triggers) and unmappable triggers in 5 (Group 1B), with 10 patients showing no inducible arrhythmia (Group 1C). After 12-month follow-up, Group 1B showed significantly higher recurrence than all other groups (60.0% vs. Group 1A: 5.7%, Group 1C: 0%, and Group 2: 14.6%; Conclusions: Continuous low-dose ISP challenge provides a pragmatic approach for intraprocedural AF trigger identification, particularly under conscious sedation. The high recurrence rate in patients with unmappable triggers underscores the imperative for advanced mapping modalities to precisely localize arrhythmogenic foci origins.
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