ArticleClinical interventions in aging2025
Sex Differences in the Association Between Inflammatory Biomarkers (Hs-CRP, IL-6, IL-10, TNF-α) and Frailty in Hospitalized Adults Aged ≥65 in Taizhou, China: A Cross-Sectional Study.
Article in Clinical interventions in aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Baseline cardio-kidney-metabolic syndrome, its transition, and frailty: insights from the China Health and Retirement Longitudinal Study (CHARLS).European journal of medical research · 2026Article
- New insights into the association between cardiometabolic index with metabolic profile, nutritional status, and inflammaging in older adults.Frontiers in aging · 2025Article
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Authors and funding
6 authors.
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Abstract
Purpose: Frailty is a prevalent geriatric syndrome that is strongly related to systemic inflammation; nevertheless, sex differences in its association with inflammation remain poorly understood. We aimed to investigate sex-specific associations between inflammatory biomarkers and frailty in a large cohort of hospitalized older adults. Patients and Methods: This cross-sectional study with 4,438 older adults aged ≥65 years was conducted at Taizhou First People's Hospital (Taizhou, China) between 23/08/2024 and 31/05/2025. The 28-item Frailty Index (FI-28, score ≥0.25 indicates frail) was used to measure frailty. High-sensitivity CRP (hs-CRP) (immunofluorescence), interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor-alpha (TNF-α) (flow cytometry) were measured; biomarkers underwent ln-transformation. Multivariate logistic regression was used to calculate adjusted odds ratios (aORs) for frailty per 1 standard deviation (SD) rise in ln-transformed biomarkers, controlling for confounders. Sex-specific differences were evaluated using interaction tests. Results: Women experienced frailty at a higher rate than men did (37.68% vs 22.8%, P < 0.001). After adjustment, high levels of IL-6, hs-CRP, and IL-10 in frail older adults were significantly linked to frailty risk (all P < 0.001). Nevertheless, TNF-α did not (p = 0.983). The relationship of frailty with IL-6, hs-CRP, and IL-10 was found to be significantly altered by sex, according to interaction tests (P Conclusion: In older adults, elevated levels of hs-CRP, IL-6, and IL-10 are associated with higher frailty risk; the associations are significantly stronger in women than in men. These findings emphasize considering sex differences in frailty management; however, longitudinal studies are required to confirm causality.
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