Evidence map›Paper›PMID 41358181›Full record

ArticleWorld journal of gastroenterology2025

Distal small bowel resection with preservation of the terminal ileum suppresses hepatic gluconeogenesis

Chi-Ying Xu, Zhi-Hua Zheng, Kun Yang, Ren-Ran Wu, Jia-Qing Cao, Jin-Yuan Duan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chi-Ying XuDepartment of General Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330000, Jiangxi Province, China.
Zhi-Hua ZhengDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330000, Jiangxi Province, China.
Kun YangDepartment of General Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330000, Jiangxi Province, China.
Ren-Ran WuDepartment of General Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330000, Jiangxi Province, China.
Jia-Qing CaoDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330000, Jiangxi Province, China.
Jin-Yuan DuanDepartment of General Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330000, Jiangxi Province, China. duanjy2022@outlook.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDistal small bowel resection with preservation of the terminal ileum (DBRPI) significantly improves glucose metabolism in rats.

aimTo explore the underlying mechanisms of DBRPI in improving glucose metabolism.

methodsFollowing 8 weeks of a high-fat diet, the rats were randomly divided into the DBRPI group and the sham operation group. After surgery, body weight and glucose tolerance were monitored. At 6 weeks post-surgery, the composition of intestinal microbiota, bile acid levels, and the expression of farnesoid X receptor (FXR), Takeda G protein-coupled receptor 5, and glucagon-like peptide-1 (GLP-1) in the ileum were examined. Additionally, the gene expression of key enzymes involved in gluconeogenesis in the liver was evaluated.

resultsDBRPI reduced body weight and improved glucose tolerance. At 6 weeks post-surgery, the abundance of

conclusionDBRPI inhibits hepatic gluconeogenesis and improves glucose metabolism. The mechanism may be related to activation of the 7-KLCA-FXR signaling pathway mediated by the

Indexed as

GluconeogenesisIleumLiverAnimalsBile Acids and SaltsBlood GlucoseDiet, High-FatDisease Models, AnimalGastrointestinal MicrobiomeGlucagon-Like Peptide 1Intestine, SmallMaleRatsRats, Sprague-DawleyReceptor, Farnesoid X-ActivatedReceptors, Cytoplasmic and NuclearBile Acids and SaltsBlood GlucoseGlucagon-Like Peptide 1Receptor, Farnesoid X-ActivatedReceptors, Cytoplasmic and NuclearBariatric surgeryBile acidsGluconeogenesisGut microbiotaMid to distal bowel resection

Identifiers

PMID41358181
PMCPMC12678930

What Socratic holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.