ArticleBreast cancer (Dove Medical Press)2025
Tissue- and Cell-Type-Specific Genetic Regulation of CTBP1 in Breast Cancer: Integrative Analyses with Exploratory Single-Cell and Imaging Data.
Article in Breast cancer (Dove Medical Press), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Background: CTBP1, an NADH-dependent transcriptional co-repressor subject to succinylation, may orchestrate both systemic and cell-type-specific effects on tumor development. Methods: This integrative study represents a novel approach, combining genetic regulation, single-cell expression quantitative trait loci (eQTLs), and imaging radiomics to investigate CTBP1 in breast cancer. We integrated tissue-relevant eQTLs with breast cancer GWAS to evaluate genetically proxied associations for CTBP1. We further explored cell-type-dependent effects using single-cell eQTL resources and examined expression, survival, and imaging correlations as hypothesis-generating evidence. Results: Tissue-focused analyses suggested an inverse association between CTBP1 expression and breast cancer risk, with consistent directions observed in expression and survival datasets. Single-cell explorations indicated potential cell-type-specific regulation.Imaging correlations with MRI-derived features were modest and exploratory. Conclusion: Our results prioritise CTBP1 as a context-dependent, tissue- and cell-type-specific candidate in breast cancer. The observational and exploratory components warrant validation in larger cohorts and functional assays. To our knowledge, this is the first integrative study combining GWAS, single-cell eQTL and MRI radiomics to prioritize CTBP1 in breast cancer.
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