Evidence map›Paper›PMID 41358315›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Low frequency BOLD oscillations,

Trevor Lohman, Arunima Kapoor, Allison C Engstrom, Jillian Joyce, Melanie Quiring, John Paul M Alitin, Aimee Gaubert, Amy Nguyen, Elizabeth Head, Rond Malhas and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Trevor LohmanDepartment of Neurology, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA.ORCID 0000-0002-9634-702X
Arunima KapoorDepartment of Psychological Science, University of California, Irvine, Irvine, CA, USA.ORCID 0000-0003-4622-8951
Allison C EngstromDepartment of Psychological Science, University of California, Irvine, Irvine, CA, USA.
Jillian JoyceUniversity of Southern California, Leonard Davis School of Gerontology, Los Angeles, CA, USA.
Melanie QuiringUniversity of Southern California, Leonard Davis School of Gerontology, Los Angeles, CA, USA.
John Paul M AlitinUniversity of Southern California, Leonard Davis School of Gerontology, Los Angeles, CA, USA.
Aimee GaubertUniversity of Southern California, Leonard Davis School of Gerontology, Los Angeles, CA, USA.
Amy NguyenUniversity of Southern California, Leonard Davis School of Gerontology, Los Angeles, CA, USA.
Elizabeth HeadDepartment of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA.
Rond MalhasDepartment of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA.
Kathleen E RodgersCenter for Innovations in Brain Science, Department of Pharmacology, University of Arizona, Tucson, AZ, USA.
David BradfordCenter for Innovations in Brain Science, Department of Pharmacology, University of Arizona, Tucson, AZ, USA.
Basant LashinUniversity of Southern California, Leonard Davis School of Gerontology, Los Angeles, CA, USA.
S Duke HanDepartment of Psychology, University of Southern California, Los Angeles, CA.
Mara MatherUniversity of Southern California, Leonard Davis School of Gerontology, Los Angeles, CA, USA.ORCID 0000-0003-4331-6112
Daniel A NationUniversity of Southern California, Leonard Davis School of Gerontology, Los Angeles, CA, USA.ORCID 0000-0002-9123-0658

Funding

Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's DiseaseP01AG052350 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ARTHUR W TOGA · 2016 to 2026
$28.4M
The Alzheimer's Disease Research Center at the University of California, IrvineP30AG066519 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Elizabeth Head · 2020 to 2026
$27.9M
USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8M
Mentored Career DevelopmentKL2TR001854 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Elizabeth Rhea Erwin Burner, Amy Elizabeth West · 2016 to 2026
$9.0M
Locus Coeruleus Imaging Markers in Preclinical Alzheimers disease, Cerebrovascular Disease and Cognitive DeclineR01AG082073 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BONDI, MARK W, MATHER, MARA · 2023 to 2025
$4.9M
Endothelial progenitor cells and neurovascular injury in the aging brainR01AG064228 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation · 2019 to 2026
$4.5M
Cerebrovascular resistance in cognitive aging and Alzheimer's disease riskR01AG060049 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NATION, DANIEL A · 2020 to 2023
$2.4M
Mid-Career Development and Mentoring on Financial Vulnerability and Alzheimer's DiseaseK24AG081325 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DUKE HAN · 2023 to 2026
$798k
NCATS NIH HHS KL2 TR001854NIA NIH HHS K24 AG081325NIA NIH HHS P01 AG052350NIA NIH HHS P30 AG066519NIA NIH HHS P30 AG066530NIA NIH HHS R01 AG060049NIA NIH HHS R01 AG064228NIA NIH HHS R01 AG082073
6 · The paper itself

Abstract

Background: Intrinsic low frequency oscillations in BOLD signal (BOLD-LFOs) are generally considered nuisance signal in connectivity analysis and discarded. However, recent evidence suggests BOLD-LFOs may shed light on cerebrovascular dysfunction and early Alzheimer's disease pathophysiology, but the mechanisms remain unclear. No investigations to date have assessed the relationship between BOLD-LFOs and plasma pTau Methods: Independently living older adults (N=118) without major neurological or psychiatric disorder were recruited from the community. Participants underwent resting-state brain functional MRI and venipuncture. Total BOLD-LFOs were quantified as signal power within the 0.01-0.10 Hz frequency range. Plasma level of pTau Results: The interactive effect of Conclusion: Present study findings suggests that BOLD-LFOs are implicated early in AD pathophysiology in an

Indexed as

Alzheimer’s DiseaseAPOE4BOLD oscillationsneuroimaging biomarkerpTau217

Identifiers

PMID41358315
PMCPMC12676400

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.