Evidence map›Paper›PMID 41358336›Full record

ReviewFrontiers in plant science2025

Next-generation biostimulants: molecular insights, digital integration, and regulatory frameworks for sustainable agriculture.

Manamele D Mashabela, Tarekegn Terefe, Pavel Kerchev, Lungile Sitole, Msizi I Mhlongo

Abstract readReview
In one paragraph

Review in Frontiers in plant science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Special Issue: "Molecular Mechanisms of Plant Biostimulants".International journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Manamele D MashabelaImbewu Metabolomics Research Group, Department of Biochemistry, Faculty of Science, University of Johannesburg, Johannesburg, South Africa.
Tarekegn TerefeResearch Centre for Plant Metabolomics, Faculty of Science, University of, Johannesburg, South Africa.
Pavel KerchevDepartment of Stress, Development and Signalling in Plants, Estación Experimental del Zaidín, Consejo Superior de Investigaciones Científicas (CSIC), Granada, Spain.
Lungile SitoleDivision of Medical Biochemistry and Structural Biology, Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Msizi I MhlongoImbewu Metabolomics Research Group, Department of Biochemistry, Faculty of Science, University of Johannesburg, Johannesburg, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of biostimulants is undergoing a critical evolution, shifting from empirical applications toward precisely engineered solutions. However, this transition is hampered by fundamental gaps, inclusive of: (1) the absence of temporal-technological frameworks connecting biostimulants development with broader agricultural revolutions, (2) insufficient mechanistic understanding linking molecular modes of action to precision application strategies, and (3) unclear regulatory frameworks and integration pathways for biostimulants within digital agriculture ecosystems (AI/IoT). This review synthesises the evolution of biostimulants through a generational framework (1.0-4.0) and examines their integration with Agriculture 5.0 technologies. We analyse classifications, molecular mechanisms, and regulatory frameworks while evaluating omics-driven precision biostimulant formulations for AI/IoT integration. Our analysis suggests that successful integration requires coordinated molecular validation, regulatory harmonisation, and digital platform development, providing researchers and policymakers with a roadmap for advancing biostimulants science from fragmented research toward systematic, technology-enabled solutions for climate-smart and sustainable agriculture, in line with SDGs 2, 13, and 15.

Indexed as

agriculture 5.0biostimulantsclimate-smart agricultureomicsPGPRregulationseaweed extracts

Identifiers

PMID41358336
PMCPMC12678307

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.