ArticleAmerican journal of men's health
Mendelian Randomization Analyses Support Causal Relationships Between Psychiatric Disorders and Risk of Urinary Tract Infections.
Article in American journal of men's health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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7 authors.
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Abstract
Observational studies have identified a significant co-morbidity between urinary tract infections (UTIs) and psychiatric disorders, yet the causal relationship remains uncertain. We conducted a bidirectional Mendelian randomization (MR) analysis to evaluate the causal relationship between psychiatric disorders (schizophrenia [SC], bipolar disorder [BD], major depressive disorder [MDD], autism spectrum disorder [ASD], attention-deficit/hyperactivity disorder [ADHD], obsessive-compulsive disorder [OCD], anorexia nervosa [AN]) and UTIs using data from the Psychiatric Genomics Consortium and UK Biobank. To account for potential confounding factors and investigate the independent effects of multiple psychiatric disorders, we further employed multivariable Mendelian randomization (MVMR). Inverse variance weighted analysis demonstrated that genetic susceptibilities of MDD and ASD increased UTI risk with odds ratios (ORs) of 1.31 (95% CI: 1.15-1.48,
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