Evidence map›Paper›PMID 41358816›Full record

ReviewFEMS microbiology reviews2026

Phage cocktails: state-of-the-art technologies and strategies for effective design.

Tomoyoshi Kaneko, Kanata Nakatsuka, Satoshi Tsuneda

Abstract readReview
In one paragraph

Review in FEMS microbiology reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Phage as a prospective arsenal against superbugs.Molecular biology reports · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tomoyoshi KanekoDepartment of Life Science and Medical Bioscience, Waseda University, Tokyo, 162-8480, Japan.ORCID 0000-0003-4857-4700
Kanata NakatsukaDepartment of Life Science and Medical Bioscience, Waseda University, Tokyo, 162-8480, Japan.ORCID 0009-0001-2446-2563
Satoshi TsunedaDepartment of Life Science and Medical Bioscience, Waseda University, Tokyo, 162-8480, Japan.ORCID 0000-0002-4624-5359

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the growing severity of antimicrobial resistance (AMR), phage therapy has garnered attention as a novel therapeutic alternative. In particular, phage cocktails, which combine multiple phages, potentially offer broader antimicrobial spectra than single-phage applications and may suppress the emergence of resistant bacteria. This comprehensive review systematically examines cutting-edge technologies and effective strategies for designing phage cocktails. Special attention was given to the combination of phages recognizing different receptors, designs based on phage-bacteria infection network analysis, and synergistic effects with antibiotics. Additionally, the analysis of large-scale clinical studies has identified challenges in practical implementation, including ensuring cocktail stability and addressing immune responses. These insights are expected to contribute to the design of more effective phage cocktails and the establishment of novel therapeutic strategies to address AMR.

Indexed as

BacteriaBacterial InfectionsBacteriophagesPhage TherapyAnti-Bacterial AgentsHumansAnti-Bacterial AgentsAMRbacteriophageclinical applicationESKAPEphage cocktailphage resistancephage therapy

Identifiers

PMID41358816
PMCPMC12776354

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.