Evidence map›Paper›PMID 41359128›Full record

ReviewWorld journal of microbiology & biotechnology2025

Harnessing microalgae for bioproducts: innovations in synthetic biology.

Zheng Li, Yuhui Cheng, Chengcheng Li, Qianyi Wu, Yi Xin

Abstract readReview
PubMed Publisher
In one paragraph

Review in World journal of microbiology & biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zheng LiSchool of Marine Biology and Fisheries, Hainan University, Haikou, 570228, China.
Yuhui ChengSchool of Marine Biology and Fisheries, Hainan University, Haikou, 570228, China.
Chengcheng LiSchool of Marine Biology and Fisheries, Hainan University, Haikou, 570228, China.
Qianyi WuSchool of Marine Biology and Fisheries, Hainan University, Haikou, 570228, China.
Yi XinSchool of Marine Biology and Fisheries, Hainan University, Haikou, 570228, China. xinyi@hainanu.edu.cn.

Funding

National Key Research and Development Program of China 2018YFA0902500National Natural Science Foundation of China 32560020 and 31600059Open Project of State Key Laboratory of Marine Resource Utilization in South China Sea DC2300001799Start-Up Funds of Hainan University RZ2300002678
6 · The paper itself

Abstract

Microalgae are increasingly recognized as versatile platforms for sustainable production of biofuels and high-value bioproducts such as lipids, carotenoids and polyunsaturated fatty acids. Rapid progress in synthetic biology is transforming microalgal engineering by enabling precise rewiring of metabolic pathways and overcoming long-standing technical bottlenecks, particularly those related to transformation efficiency, genetic stability and strain scalability. Recent innovations (including CRISPR/Cas genome editing, modular cloning systems, synthetic promoter libraries and dynamic, environment-responsive regulatory circuits) have greatly expanded the genetic toolset available for both model and recalcitrant species. These advances support targeted control of lipid and pigment biosynthesis, improved flux distribution and more robust performance under industrially relevant conditions. When integrated with progress in photobioreactor design, automated cultivation, and process intensification, synthetic biology unlocks new potential for scalable, economically viable microalgal biomanufacturing. This review summarizes these developments, highlights remaining challenges in strain robustness and bioprocess translation, and outlines future pathways toward high-performance microalgal biofactories that can contribute meaningfully to a low-carbon, bio-based economy.

Indexed as

Metabolic EngineeringMicroalgaeSynthetic BiologyBiofuelsCRISPR-Cas SystemsGene EditingLipidsMetabolic Networks and PathwaysPhotobioreactorsBiofuelsLipidsBioproductsLipid metabolismMicroalgaeSynthetic biology

Identifiers

PMID41359128

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.