Evidence map›Paper›PMID 41359162›Full record

ArticleCellular and molecular life sciences : CMLS2025

IER3 drives the transition from sepsis-associated AKI to CKD by suppressing the mitochondrial translocation of PRDX5.

Qian Dou, Hang Tong, Juan Chen, Xiangling Yi, Lihua Bai, Junling He, Kehong Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qian Dou *Department of Nephrology, Daping Hospital, Chongqing Key Laboratory of Precision Diagnosis and Treatment for Kidney Diseases, Army Medical University, Chongqing, 400042, China.
Hang Tong *Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Juan Chen *Department of Nephrology, Daping Hospital, Chongqing Key Laboratory of Precision Diagnosis and Treatment for Kidney Diseases, Army Medical University, Chongqing, 400042, China.
Xiangling YiDepartment of Nephrology, Daping Hospital, Chongqing Key Laboratory of Precision Diagnosis and Treatment for Kidney Diseases, Army Medical University, Chongqing, 400042, China.
Lihua BaiDepartment of Nephrology, Daping Hospital, Chongqing Key Laboratory of Precision Diagnosis and Treatment for Kidney Diseases, Army Medical University, Chongqing, 400042, China.
Junling HeDepartment of Nephrology, Daping Hospital, Chongqing Key Laboratory of Precision Diagnosis and Treatment for Kidney Diseases, Army Medical University, Chongqing, 400042, China.
Kehong ChenDepartment of Nephrology, Daping Hospital, Chongqing Key Laboratory of Precision Diagnosis and Treatment for Kidney Diseases, Army Medical University, Chongqing, 400042, China. chenkh@tmmu.edu.cn.ORCID http://orcid.org/0009-0006-7387-2901

Funding

National Natural Science Foundation of China 82270768, 8240035944National Natural Science Foundation of China 82400847
6 · The paper itself

Abstract

Sepsis-associated acute kidney injury (SAKI) is a severe condition associated with high mortality and long-term complications. Currently, there is no effective strategy to halt AKI chronicization. Stress-induced senescence of renal tubular epithelial cells (RTECs) is a pivotal driving mechanism in the AKI-CKD transition. Previous scRNA-seq revealed that the expression of immediate early response gene 3 (IER3) was markedly upregulated in the senescent RTECs of patients with AKI and that the IER3

Indexed as

Acute Kidney InjuryMitochondriaPeroxiredoxinsRenal Insufficiency, ChronicSepsisAnimalsCellular SenescenceEpithelial CellsHumansKidney TubulesMaleMiceMice, Inbred C57BLMice, KnockoutProtein TransportPeroxiredoxinsAKI-to-CKD transitionIER3PRDX5Sepsis-associated AKIStress-induced senescence

Identifiers

PMID41359162
PMCPMC12686328

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.