ArticleDiscover oncology2025
A higher number of chemotherapy cycles given during and after radiation is linked to increased rates of radiation-induced trismus in locally advanced nasopharyngeal cancer patients.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimTo investigate the impact of the number of chemotherapy cycles (NCTC) on the occurrence of radiation-induced trismus (RIT) in locally advanced nasopharyngeal cancer (LA-NPC) patients who underwent definitive concurrent chemoradiotherapy (CCRT) followed by consolidation chemotherapy. MATERIALS AND
methodsA retrospective analysis was conducted on LA-NPC patients who underwent CCRT between July 2011 and March 2024. The cohort was categorized based on the NCTC (< 3 vs. ≥ 3) and total NCTC (TNCTC: < 4 vs. ≥ 4). The primary objective of this study was to investigate the correlation between the RIT [a maximum mouth opening (MMO) of ≤ 35 mm] incidence and the NCTC and TNCTC parameters.
resultsA total of 293 patients were included in the study. The incidence of RIT was significantly higher in patients receiving NCTC ≥ 3 (32.5% vs.16.9%; P < 0.001) and TNCTC ≥ 4 (32.4% vs.15.0; P < 0.001). Univariate analysis identified NCTC ≥ 3 (P < 0.001), TNCTC ≥ 4 (P < 0.001), smoking history (P = 0.03), pre-treatment MMO < 41 mm (P = 0.003), and advanced tumor stage (T3-4) (P < 0.001) as independent predictors of RIT. Multivariate analysis revealed that all factors were independent and significant predictors of RIT in this patient group (P < 0.05 for each).
conclusionThe findings of this retrospective study indicate that higher NCTC and TNCTC are independently correlated with an increased risk of RIT in LA-NPC patients undergoing CCRT.
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