Evidence map›Paper›PMID 41359391›Full record

ArticleKidney3602026

Longitudinal Assessment of Health-Related Quality of Life in Adults with CKD.

Owen Ng, Armando Teixeira-Pinto, Anh Kieu, Anita van Zwieten, Anoushka Krishnan, Kirsten Howard, Wai H Lim, Jeremy R Chapman, Simon D Roger, Michael J Bourke and 7 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney360, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Owen NgCentre for Kidney Research, Kids Research Institute, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.ORCID 0009-0005-9414-675
Armando Teixeira-PintoCentre for Kidney Research, Kids Research Institute, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.ORCID 0000-0002-9389-2516
Anh KieuCentre for Kidney Research, Kids Research Institute, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
Anita van ZwietenCentre for Kidney Research, Kids Research Institute, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.ORCID 0000-0003-4564-5825
Anoushka KrishnanCentre for Kidney Research, Kids Research Institute, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
Kirsten HowardSydney School of Public Health, University of Sydney, Sydney, New South Wales, Australia.
Wai H LimSchool of Medical and Health Science, Edith Cowan University, Perth, Western Australia, Australia.ORCID 0000-0002-3410-3572
Jeremy R ChapmanDepartment of Renal and Transplant Medicine, Westmead Hospital, Sydney, New South Wales, Australia.
Simon D RogerDepartment of Renal Medicine, Gosford Hospital, Gosford, New South Wales, Australia.ORCID 0000-0002-8299-2650
Michael J BourkeDepartment of Gastroenterology, Westmead Hospital, Westmead, University of Sydney, Sydney, New South Wales, Australia.
Shaundeep SenDepartment of Renal Medicine, Concord Repatriation General Hospital, Concord, New South Wales, Australia.
Steven J ChadbanDpartment of Renal Medicine, Royal Prince Alfred Hospital, and Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-0527-898
Carol A PollockDepartment of Medicine, Northern Clinical School, Kolling Institute of Medical Research, Sydney, New South Wales, Australia.ORCID 0000-0001-7167-6495
Allison JaureCentre for Kidney Research, Kids Research Institute, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.ORCID 0000-0001-8973-9538
Jonathan C CraigCollege of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.ORCID 0000-0002-2548-4035
Jean YangSchool of Mathematics and Statistics, University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-5271-2603
Germaine WongCentre for Kidney Research, Kids Research Institute, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.ORCID 0000-0001-8422-7269

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

key pointsDialysis linked with poorer quality of life compared with transplant patients and patients with CKD. Quality of life trends were similar in both domain-specific and overall quality-of-life measures.

backgroundThere are sparse data about the change in health-related quality of life (HRQoL) with the temporal progression of CKD. In this study, we assessed the association between change in CKD stages, overall and domain-specific quality of life and determined the factors that were associated with this change.

methodsData were sourced from a multicenter study that included 1290 adult patients aged 18 years and older across six centers in Australia. Three-level EuroQol five-dimensional questionnaire was collected at baseline and 2 and 4 years. Changes in CKD stages were treated as a time-varying exposure; generalized estimating equations were used to model the changes in HRQoL.

resultsWith reference to patients with CKD (G3-5), patients treated with dialysis had a reduction of 0.06 (-0.09 to -0.04) in overall HRQoL scores over the 4 years and experienced higher odds of reporting lower HRQoL across all domains: mobility (1.91 [1.53-2.38]), self-care (2.30 [1.67-3.16]), usual activity (2.70 [2.18-3.38]), pain (1.19 [0.97-1.46]), and anxiety (1.40 [1.12-1.75]). Transplant recipients showed no significant decline in overall HRQoL ( P = 0.13), but had increased odds of reduced mobility (1.74 [1.40-2.18]) and usual activity (1.35 [1.07-1.71]). Female sex, smoking, prevalent diabetes mellitus, lower educational attainment, and Middle Eastern ethnicity were associated with lower HRQoL.

conclusionsPatients on maintenance dialysis, but not transplant recipients, experienced a significant decline in overall HRQoL (0.06) over the 4 years compared with patients with CKD (G3-5). These utility-based HRQoL estimates are essential for future economic evaluations in kidney trials.

Indexed as

Quality of LifeRenal DialysisRenal Insufficiency, ChronicAdultAgedAustraliaDisease ProgressionFemaleHumansLongitudinal StudiesMaleMiddle AgedSurveys and QuestionnairesCKDdialysiskidney transplantationquality of life

Identifiers

PMID41359391
PMCPMC13134796

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.