Evidence map›Paper›PMID 41360721›Full record

ArticleBritish journal of haematology2026

Risk factors for silent cerebral infarction in immune-mediated thrombotic thrombocytopenic survivors.

Binish Javed, Jia Yu, Jenna Brown, Jay Meade, Gloria F Gerber, Michael B Streiff, Peggy Kraus, Samuel Merrill, Allyson M Pishko, Jennifer Yui and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of haematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Binish JavedDivision of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Jia YuSchool of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Jenna BrownDivision of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Jay MeadeDivision of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Gloria F GerberDivision of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Michael B StreiffDivision of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Peggy KrausDivision of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Samuel MerrillDivison of Hematology and Oncology, Department of Medicine, West Virginia University, Morgantown, West Virginia, USA.
Allyson M PishkoDivison of Hematology and Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0001-9997-454X
Jennifer YuiDivision of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Rakhi P NaikDivision of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Robert A BrodskyDivision of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0001-5741-1255
Doris D LinDivision of Neuroradiology, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Shruti ChaturvediDivision of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Funding

Targeting silent cerebral infarction to improve long-term neurologic outcomes in immune thrombotic thrombocytopenic purpura (iTTP)R00HL172303 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Shruti Chaturvedi · 2024 to 2026
$1.3M
ADAMTS13 and Late Neurologic Morbidity after Thrombotic Thrombocytopenic PurpuraK99HL150594 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CHATURVEDI, SHRUTI · 2020 to 2023
$907k
American Society of HematologyNHLBI NIH HHS K99 HL150594NHLBI NIH HHS R00 HL172303NIH HHS R00HL172303
6 · The paper itself

Abstract

Immune-mediated thrombotic thrombocytopenic purpura (iTTP) survivors are predisposed to silent cerebral infarctions (SCI) defined as radiological evidence of brain ischaemia without focal symptoms. This study examined risk factors associated with SCI burden in iTTP survivors during remission. We included the first 39 iTTP survivors enrolled in the prospective neurological sequelae of TTP (NeST) study. Participants underwent brain magnetic resonance imaging during clinical remission. SCI burden was quantified using the modified age-related white matter changes (ARWMC) score. Multivariate linear regression models identified the predictors of SCI burden. Of 39 participants, 20 (51.3%) had SCI. On univariate analysis, higher SCI burden was associated with older age, elevated level of peak serum creatinine and peak lactate dehydrogenase (LDH) during the index iTTP episode, comorbidities including diabetes mellitus, prior stroke, coronary artery disease (CAD) and family history of cerebrovascular disease. In the multivariate model, higher SCI burden was significantly associated with older age (p < 0.001), diabetes mellitus (p = 0.007), prior stroke (p = 0.01), CAD (p = 0.02) and elevated peak LDH (p = 0.046). Total days of thrombocytopenia (surrogate for 'days with active iTTP') were not associated with SCI burden. Both modifiable and non-modifiable factors contribute to SCI in iTTP survivors. Targeted management of cardiovascular comorbidities during remission may reduce long-term neurological sequelae. Validation in larger cohorts is needed.

Indexed as

Cerebral InfarctionPurpura, Thrombotic ThrombocytopenicAdultAgedFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesRisk FactorsSurvivorsmagnetic resonance imagingsilent cerebral infarctionthrombotic thrombocytopenic purpura

Identifiers

PMID41360721
PMCPMC12916186

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.