Evidence map›Paper›PMID 41360797›Full record

ArticleNature communications2025

Discovery of a β-arrestin-biased CCKBR agonist that blocks CCKBR-dependent long-term potentiation.

Heng Shi, Mengfan Zhang, Xiaofeng Hu, Jie Zhang, Tao Chen, Pingzhou Wu, Xue Wang, Shu Wei, George Choy, Stephen Temitayo Bello and 5 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Heng Shi *Department of Neuroscience, City University of Hong Kong, Kowloon, Hong Kong.ORCID http://orcid.org/0000-0002-8695-7449
Mengfan Zhang *Department of Neuroscience, City University of Hong Kong, Kowloon, Hong Kong.ORCID http://orcid.org/0000-0002-5320-5742
Xiaofeng HuDepartment of Neuroscience, City University of Hong Kong, Kowloon, Hong Kong.
Jie ZhangCenter of Regenerative Medicine and Health, Hong Kong Institute of Science and Innovation, Chinese Academy of Sciences, Kowloon, Hong Kong.
Tao ChenDepartment of Neuroscience, City University of Hong Kong, Kowloon, Hong Kong.
Pingzhou WuDepartment of Chemistry, City University of Hong Kong, Kowloon, Hong Kong.
Xue WangDepartment of Neuroscience, City University of Hong Kong, Kowloon, Hong Kong.
Shu WeiDepartment of Neuroscience, City University of Hong Kong, Kowloon, Hong Kong.
George ChoyDepartment of Neuroscience, City University of Hong Kong, Kowloon, Hong Kong.ORCID http://orcid.org/0009-0001-5451-2330
Stephen Temitayo BelloDepartment of Neuroscience, City University of Hong Kong, Kowloon, Hong Kong.
Huifeng ChenDepartment of Neuroscience, City University of Hong Kong, Kowloon, Hong Kong.
Chunhua LiuInnovation Centre for Advanced Interdisciplinary Medicine, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510799, China.
Yiping GuoGuangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong Province, China.ORCID http://orcid.org/0000-0003-1628-8312
Hongyan SunDepartment of Chemistry, City University of Hong Kong, Kowloon, Hong Kong.ORCID http://orcid.org/0000-0003-0932-6405
Jufang HeDepartment of Neuroscience, City University of Hong Kong, Kowloon, Hong Kong. jufanghe@cityu.edu.hk.ORCID http://orcid.org/0000-0002-4288-5957

Funding

Research Grants Council, University Grants Committee (RGC, UGC) C1043-21GResearch Grants Council, University Grants Committee (RGC, UGC) CityUHK 11101521, CityUHK 11103922, CityUHK 11104923, CityUHK 11104524.Research Grants Council, University Grants Committee (RGC, UGC) SRFS2324-1S02Research Grants Council, University Grants Committee (RGC, UGC) T13-605/18-W
6 · The paper itself

Abstract

The CCKBR agonists induce neocortical long-term potentiation of excitatory synaptic transmission and enhance memory formation, while its antagonists weaken the potentiation in the amygdala and alleviate depression-like behaviors. However, the mechanism that drives CCKBR dependent long-term potentiation remains elusive. There is also no signaling pathway-biased CCKBR agonist to modulate the potentiation. Here, we discover a β-arrestin biased CCKBR agonist MF-8 with IC

Indexed as

beta-ArrestinsLong-Term PotentiationAnimalsEndocytosisFearHEK293 CellsHumansMaleMemoryMiceMice, Inbred C57BLSignal Transductionbeta-Arrestins

Identifiers

PMID41360797
PMCPMC12686490

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.