ArticleScientific reports2025
Comparison of prevalence of fatty liver disease according to the different nomenclatures of NAFLD, MAFLD, and MASLD in a large Iranian Population-based study.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Higher adherence to the EAT-lancet diet is associated with reduced risk of metabolic dysfunction-associated steatotic liver disease: a 5-year middle eastern cohort study.Diabetology & metabolic syndrome · 2026Article
- Association of general obesity, metabolically healthy obesity, and abdominal adiposity markers with elevated liver enzymes: a population-based study.Scientific reports · 2026Article
- The HepG2 Cell Line as a Model for Studying Metabolic Dysfunction-Associated Steatotic Liver Disease.International journal of molecular sciences · 2026Review
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5 authors.
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Abstract
The terminology and diagnostic criteria for fatty liver disease have undergone recent evolution, from non-alcoholic fatty liver disease (NAFLD) to metabolic dysfunction-associated fatty liver disease (MAFLD), and more recently to metabolic dysfunction-associated steatotic liver disease (MASLD). We aimed to compare the estimated prevalence of FLD with that of NAFLD, MAFLD, and MASLD using different definitions. Data were analyzed from 10,520 participants in the first phase of the Guilan Persian Cohort Study, part of the nationwide PERSIAN Cohort. Participants were classified based on NAFLD, MAFLD, and MASLD. Of 10,520 participants, 5,025 (47.8%) had a fatty liver index (FLI) ≥ 60 and were diagnosed with SLD. The prevalence of MASLD, MAFLD, and NAFLD was 33.7%, 47.6%, and 33.7%, respectively, while 4.5% (n = 471) were classified as metabolic dysfunction-associated alcohol-related liver disease (MetALD). Among those with NAFLD, 99.7% also met MAFLD criteria, and all met MASLD criteria. MAFLD was associated with the highest adjusted odds of elevated FIB-4 (OR: 1.27; 95% CI: 1.24-1.30) and hepatic steatosis index (OR: 2.01; 95% CI: 1.82-2.21). NAFLD and MASLD had a similar, lower prevalence compared to MAFLD. MetALD was not included under MASLD but was encompassed by MAFLD.
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