ArticleNPJ Parkinson's disease2025
Brain age gap as predictor of disease progression in Parkinson's disease.
Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Association of imaging-defined brain age with disease severity and adverse outcomes in CADASIL.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
Parkinson's disease (PD) exhibits high heterogeneity in disease progression, complicating management and increasing required sample sizes for clinical trials. This study evaluates Brain Age Gap (BAG)-the difference between brain age and chronological age-for predicting disease progression in PD. Structural MRI-derived gray matter volumes were analyzed for 451 early-stage PD patients and 172 healthy controls from the PPMI cohort. PD patients had a baseline BAG of 1.1 years, with fast-progressing patients exhibiting a BAG of 3.0 years, whereas slow-progressing patients resembled the BAG of healthy controls. Higher BAG was associated with more severe baseline symptoms, faster cognitive decline in several domains, increased hazard of developing mild cognitive impairment, and faster progression of dopaminergic neuron loss in longitudinal DaTSCANs. BAG-based patient stratification could reduce sample sizes of randomized clinical trials by 23-58%. These findings suggest BAG as a prognostic biomarker of disease progression, which may accelerate the development of disease-modifying treatments.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.