ArticleBMC medicine2025
Maternal probiotics intake during pregnancy and exclusive colostrum breastfeeding are associated with a reduced risk of neonatal jaundice.
Article in BMC medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeonatal jaundice (NJ), characterized by significantly increased bilirubin levels, is a prevalent global neonatal condition affecting 60-80% of newborns. It imposes long-term adverse effects on neurodevelopment and overall health. Current clinical treatments, such as phototherapy, primarily focus on symptom management, whereas the preventive strategies for NJ remain largely lacking. Infant breastfeeding is associated with NJ. However, whether maternal probiotics use and infant colostrum feeding may reduce the NJ risk has yet to be determined and warrants further investigation in large-scale cohorts. Therefore, this study aimed to evaluate whether they have any preventive effect.
methodsWe investigated the relationship of maternal probiotic intake and baby feeding type with NJ onset using the CHILD cohort, a prospective birth cohort recruited 3624 mothers and 3542 paired infants. Probiotic intake during pregnancy and its patterns (increased, maintained, or decreased compared to preconception) were obtained via questionnaires. The NJ conditions (yes/no) and feeding modes (exclusive colostrum, formula-only, or mixed feeding) were collected from hospital birth records. Bivariate and multivariable logistic regressions were employed to evaluate the risk using adjusted odds ratio (AOR) with 95% confidence intervals (CI) after adjustment for confounders. P < 0.05 indicates statistical significance.
resultsA total of 2596 healthy controls and 433 NJ cases with complete data were included from the CHILD cohort for analysis. Interestingly, probiotic intake during pregnancy was associated with a remarkably reduced odds of NJ (AOR 0.78 (0.61, 0.98), P = 0.041) compared to participants who never used probiotics. Neonates with exclusive colostrum feeding also had a significantly lower incidence of NJ than other feeding modes (AOR 0.34 with (95%CI) (0.27,0.44), P < 0.001). Further stratification analysis on probiotic intake showed that mothers who increased (AOR 0.53 (0.32, 0.89), P = 0.016) or maintained (AOR 0.44 (0.24, 0.80), P < 0.007) probiotic intake during pregnancy had a lower risk of NJ compared to those who decreased intake.
conclusionsThis cohort-based evidence highlights that maternal probiotic intake and exclusive colostrum feeding are important modifiable factors associated with reduced NJ risk.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.