Evidence map›Paper›PMID 41361320›Full record

ReviewBiology direct2025

Effect of pesticides on breast cancer tumor.

Daniele Marcoccia, Stefano Palomba, Giovanni Brajon, Alessandro Baldi, Flavia Silvia Galli, Francesca Servadei, Valeria Palumbo, Rita Bonfiglio, Michele Treglia, Luigi Tonino Marsella and 6 more

Abstract readReview
In one paragraph

Review in Biology direct, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Daniele MarcocciaIstituto Zooprofilattico Sperimentale del Lazio e della Toscana, Lazio, Rome, Italy. daniele.marcoccia@izslt.it.ORCID http://orcid.org/0000-0003-0883-4184
Stefano PalombaIstituto Zooprofilattico Sperimentale del Lazio e della Toscana, Lazio, Rome, Italy.
Giovanni BrajonIstituto Zooprofilattico Sperimentale del Lazio e della Toscana, Lazio, Rome, Italy.ORCID http://orcid.org/0000-0002-3411-4730
Alessandro BaldiIstituto Zooprofilattico Sperimentale del Lazio e della Toscana, Lazio, Rome, Italy.
Flavia Silvia GalliIstituto Zooprofilattico Sperimentale del Lazio e della Toscana, Lazio, Rome, Italy.ORCID http://orcid.org/0009-0000-7596-6190
Francesca ServadeiDepartment of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133, Rome, Italy.ORCID http://orcid.org/0000-0003-2619-9153
Valeria PalumboDepartment of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133, Rome, Italy.ORCID http://orcid.org/0000-0001-7756-6676
Rita BonfiglioDepartment of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133, Rome, Italy.ORCID http://orcid.org/0000-0003-4172-2977
Michele TregliaLaif (laboratorio di Antropologia e Invecchiamento Forense), Sezione di medicina legale, sicurezza sociale e tossicologia forense, University of Tor Vergata, Rome, Italy.ORCID http://orcid.org/0000-0002-9434-2604
Luigi Tonino MarsellaLaif (laboratorio di Antropologia e Invecchiamento Forense), Sezione di medicina legale, sicurezza sociale e tossicologia forense, University of Tor Vergata, Rome, Italy.ORCID http://orcid.org/0000-0002-9471-3436
Flavia BottiDepartment of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133, Rome, Italy.ORCID http://orcid.org/0000-0002-7266-1014
Yufang ShiInstitutes for Translational Medicine, Suzhou Medical College, The Fourth Affiliated Hospital of Soochow University, Soochow University, Suzhou, 215000, China.ORCID http://orcid.org/0000-0001-8964-319X
Eleonora CandiDepartment of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133, Rome, Italy.ORCID http://orcid.org/0000-0001-8332-4825
Gerry MelinoDepartment of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133, Rome, Italy.ORCID http://orcid.org/0000-0001-9428-5972
Alessandro MaurielloDepartment of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133, Rome, Italy. alessandro.mauriello@uniroma2.it.ORCID http://orcid.org/0000-0002-7351-5676
Manuel ScimecaDepartment of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133, Rome, Italy. manuel.scimeca@uniroma2.it.ORCID http://orcid.org/0000-0003-0585-1309

Funding

Advanced Diagnostic- Italian network of excellence for advanced diagnosis (INNOVA) PNC-E3-2022-23683266Associazione Italiana per la Ricerca contro il Cancro (AIRC) IG 2022 ID 27366; 2023-2027Associazione Italiana per la Ricerca contro il Cancro (AIRC) IG#31044; 2024-2029European Union NextGenerationEU via MUR-PNRR M4C2-II.3 PE6 project PE00000019Fondazione Luigi Maria Monti IDI-IRCCS RC
6 · The paper itself

Abstract

Breast cancer is the most common malignancy among women worldwide. Increasing evidence suggests that chronic exposure to pesticides, many of which act as endocrine-disrupting chemicals, represents a significant and underappreciated determinant for both cancer origin and progression. In this review, we reported the most recent epidemiological data, exposure pathways, and mechanistic insights linking major pesticide classes, including persistent organochlorines, organophosphates, triazines, carbamates, pyrethroids, neonicotinoids, and glyphosate-based herbicides, to breast carcinogenesis. These compounds are ubiquitous, detectable in food, water, household dust, and occupational environments, and display high lipophilicity that enables long-term bioaccumulation in adipose-rich breast tissue. Therefore, recognition of pesticides as modifiable environmental determinants of breast cancer should prompt strengthened regulation, improved biomonitoring, and public-health strategies aimed at reducing chronic exposure.

Indexed as

Breast NeoplasmsEnvironmental ExposurePesticidesEnvironmental PollutantsFemaleHumansEnvironmental PollutantsPesticidesBreast cancerEnvironmental pollutionExposomePesticides

Identifiers

PMID41361320
PMCPMC12798136

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.