ArticleScientific reports2025
Ferritinophagy-related prognostic genes UBE2Q1, NEDD4L, and TCP11L2 for prognosis prediction in sepsis.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Sepsis remains a critical global health threat characterized by high mortality and complex immune-metabolic dysregulation. This study identifies ferritinophagy-related prognostic genes (FRGs) that are causally linked to sepsis outcomes using a multi-omics approach integrating bulk and single-cell transcriptomics with Mendelian randomization. Among 1047 candidate genes, UBE2Q1, NEDD4L, and TCP11L2 were selected to build a risk model that effectively stratified sepsis patients and predicted mortality. Functional enrichment analysis revealed associations with oxidative phosphorylation, ribosome function, and Parkinson's disease pathways. Immune infiltration analysis identified increased γδ T and NK cell levels in high-risk patients, with significant correlations to prognostic genes. Single-cell RNA sequencing further revealed dynamic gene expression shifts across key immune cell types including T cells, monocytes, and platelets. Cell-cell communication and pseudo-time analyses highlighted the roles of UBE2Q1 and NEDD4L in immune regulation and development. This study provides preliminary clues that ferritin and autophagy-related genes may be involved in the pathogenesis of sepsis, and proposes potential molecular targets that can be used for prognostic evaluation and therapeutic intervention.
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