Evidence map›Paper›PMID 41361354›Full record

SynthesisScientific reports2025

Association of HLA class I allele and tuberculosis susceptibility: a systematic review and meta-analysis.

Neha Kumari, Ravindra Kumar, Ishan K Patro, Aparup Das

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Neha KumariICMR-National Institute of Research in Tribal Health, Jabalpur, India.
Ravindra KumarICMR-National Institute of Research in Tribal Health, Jabalpur, India. Ravindra.kum@icmr.gov.in.
Ishan K PatroSchool of Studies in Zoology, Jiwaji University, Gwalior, India.
Aparup DasAcademy of Scientific and Innovative Research, Ghaziabad, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mycobacterium tuberculosis (M.tuberculosis) continues to cause one of the most pressing health burdens in the world, especially in developing nations, in the form of tuberculosis (TB). In addition to socio-environmental factors, it is widely believed that host genetic factors, particularly polymorphisms within the human leukocyte antigen (HLA) system, may play an extensive role in the likelihood of a host's TB infection. Studies on the influence of HLA class I alleles (HLA-A, -B, -C) in human susceptibility to TB reported contradictory results. Therefore, this systematic review and meta-analysis aim to see the association of HLA class I alleles with susceptibility to TB in humans. In this meta-analysis, the literature was searched using PubMed, ScienceDirect, and Google Scholar, until 23rd May 2025. A total of 13 eligible case-control studies were included, comprising 1951 TB cases and 2109 matched healthy controls. Together with a 95% Confidence interval, pooled odds ratio was calculated for each allele. To evaluate heterogeneity I

Indexed as

AllelesGenetic Predisposition to DiseaseHistocompatibility Antigens Class ITuberculosisHumansMycobacterium tuberculosisHistocompatibility Antigens Class IHLA (human leukocyte antigen)Susceptible genotypesTuberculosis

Identifiers

PMID41361354
PMCPMC12800256

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.