Evidence map›Paper›PMID 41361389›Full record

ArticleBiological procedures online2025

Listening to the Past, Shaping the Future: A Data-mining Based and Visual Analysis of Five Decades of Gastric Carcinogenesis Research.

Tai Zhang, Xudong Tang

Abstract read
In one paragraph

Article in Biological procedures online, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tai ZhangPeking University Traditional Chinese Medicine Clinical Medical School (Xiyuan), Peking University Health Science Center, 1 Caochang, Xiyuan, Beijing, 100091, People's Republic of China.
Xudong TangPeking University Traditional Chinese Medicine Clinical Medical School (Xiyuan), Peking University Health Science Center, 1 Caochang, Xiyuan, Beijing, 100091, People's Republic of China. txdly@sina.com.

Funding

Innovation Team Project of the Chinese Academy of Traditional Chinese Medicine's Scientific and Technological Innovation Program CI2021B005National Administration of Traditional Chinese Medicine's Inheritance and Innovation Team Project ZYYCXTD-C-202010Project for Enhancing the Research and Translational Capability of Traditional Chinese Medicine Hospitals XYZX0204-03Research Ward Project BCRW202108
6 · The paper itself

Abstract

backgroundGastric cancer remains a major global health concern with approximately one million new cases annually. Despite five decades of extensive research, comprehensive analysis mapping gastric carcinogenesis research evolution and emerging therapeutic frontiers remains limited. This study aims to systematically analyze the intellectual landscape, research trends, and future directions in gastric carcinogenesis research. MATERIALS AND

methodsWe analyzed 11,527 scientific publications on gastric carcinogenesis from 1970-2024 using advanced scientometric tools including CiteSpace and VOSviewer for co-citation analysis, collaboration network mapping, and keyword co-occurrence analysis.

resultsPublication output demonstrated exponential growth, peaking at 547 publications in 2022. Asia leads research productivity with China, Japan, and South Korea contributing 37.50% of total publications, while the United States exhibits highest collaborative influence with betweenness centrality of 0.45. Seven distinct research clusters emerged encompassing Helicobacter pylori pathogenesis, molecular mechanisms, precancerous lesions, autoimmune gastritis, and therapeutic interventions. Five emerging trends were identified: stromal microenvironment interactions in carcinogenesis progression, gastric organoid models for disease modeling, artificial intelligence-enhanced endoscopic detection technologies, biomarker development for early diagnosis, and traditional herbal medicine applications for chemoprevention.

conclusionsResearch gaps persist in autoimmune gastritis pathways and clinical translation of molecular discoveries. Emerging research directions encompass advanced modeling systems, molecular diagnostics, and technological applications, though their clinical impact remains to be established through future validation studies.

Indexed as

DysplasiaGastric cancerGastric carcinogenesisHelicobacter pyloriMetaplasia

Identifiers

PMID41361389
PMCPMC12817797

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.