ArticleLipids in health and disease2025
Brown adipose tissue and tumor presence: a retrospective association analysis considering the role of body mass index.
Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundBrown adipose tissue (BAT) regulates metabolic homeostasis, yet its role in tumor presence remains undefined. This study investigates the associations among BAT, body mass index (BMI), and tumor presence in a large Chinese cohort.
methodsWe retrospectively analyzed 1,736 adults who underwent
resultsThe presence of BAT was associated with younger age, female sex, and lower BMI. In multivariable logistic regression, age (p < 0.001) and BMI (p = 0.014) were independently associated with tumor presence. After propensity score matching (PSM), sex-stratified mediation analysis showed that in females, BAT was indirectly associated with a lower likelihood of tumor presence (Natural Indirect Effect OR = 0.88, 95% CI 0.72-0.98), whereas no significant mediation effect was observed in males. Among cancer patients, individuals with BAT had a significantly lower BMI compared to individuals without BAT (overall: 21.08 vs. 23.34; females: 21.33 vs. 22.97; males: 19.65 vs. 24.68).
conclusionsOur findings indicate that BAT and tumor presence are statistically associated in a sex-specific manner, with BMI potentially playing a mediating role in females. The consistently lower BMI among BAT(+) cancer patients further indicates a plausible link between BAT and body weight regulation. These observations warrant further investigation to elucidate the underlying mechanisms.
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