ArticlePsychopharmacology2025
Effect of dietary stimulation on acute changes in GLP-1, alcohol responses, craving, and attentional bias: a randomized, placebo-controlled laboratory study.
Article in Psychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
rationalePreclinical and clinical findings support the potential for GLP-1 receptor activation to reduce alcohol consumption and reward. Human experimental studies are needed to clarify whether acute changes in endogenous GLP-1 influence alcohol craving and responses to alcohol. Dietary stimulation may present a method to study the effects of endogenous GLP-1 on responses to alcohol.
objectivesAssess the effects of a dietary manipulation on acute changes in GLP-1 and laboratory responses to alcohol.
methodsHealthy young adult heavy drinkers (N = 40) were recruited to participate in two study visits where they received a dietary supplement designed to increase endogenous GLP-1 or a calorically matched placebo in counterbalanced order. Blood was sampled before and 40 min after supplement or placebo administration to measure changes in plasma GLP-1. Subjective effects, craving, and alcohol attentional bias were measured in response to a priming drink of alcohol (target BAC 30 mg%).
resultsCompared to placebo, dietary supplement preload significantly increased blood GLP-1 concentration, β = 0.79, p < 0.001, and significantly reduced alcohol attentional bias, β = -0.56, p = 0.010. Blood GLP-1 concentration correlated with the magnitude of alcohol attentional bias reduction after supplement preload (r = -0.30). There were no significant effects of the manipulation on subjective responses or craving.
conclusionsResults suggest that dietary stimulation may reduce the incentive motivational properties of alcohol-related cues, potentially through increases in endogenous GLP-1, absent effects on self-report measures of alcohol subjective response or craving. Acute changes in circulating GLP-1 may influence implicit motivation for alcohol.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.