Evidence mapPaperPMID 41361809Full record

ArticleBMC surgery2025

Impact of sarcopenia on short- and long-term outcomes following major hepatectomy for malignancy.

Kerem Özgü, Emre Teke, Mehmet Süha Sevinç, Gizem Agaran, Ayşegül Gürsoy Çoruh, Elvan Onur Kırımker

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Article in BMC surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Kerem ÖzgüDepartment of Surgery, Gaziantep City Hospital, Gaziantep, Turkey.
Emre TekeDepartment of Surgery, Gaziantep City Hospital, Gaziantep, Turkey.
Mehmet Süha SevinçDepartment of Surgery, Ankara University School of Medicine, Ankara, Turkey.
Gizem AgaranDepartment of Radiology, Ankara University School of Medicine, Ankara, Turkey.
Ayşegül Gürsoy ÇoruhDepartment of Radiology, Ankara University School of Medicine, Ankara, Turkey.
Elvan Onur KırımkerDepartment of Surgery, Ankara University School of Medicine, Ankara, Turkey. fbkerem58@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSarcopenia is increasingly recognized as a major prognostic factor in liver surgery. The present study aimed to investigate the impact of preoperative sarcopenia on postoperative morbidity and mortality following major hepatectomy for malignant liver tumours.

methodsThe present retrospective cohort study included 104 patients who underwent major hepatectomy between 2019 and 2024. Sarcopenia was assessed using preoperative computed tomography scans to calculate the L3 skeletal muscle index (L3-SMI), with established sex-specific cut-offs. Postoperative outcomes were compared between sarcopenic and nonsarcopenic patients.

resultsOf the 104 patients, 56 (53.8%) were classified as having sarcopenia. Sarcopenic patients had a significantly lower Body mass ındex (26.4 ± 3.7 vs. 28.4 ± 4.0 kg/m²; p = 0.011) and a greater proportion of males (71.4% vs. 41.7%; p = 0.002). Although there was a higher rate of postoperative morbidity in sarcopenic patients (55.3% vs. 39.6%), the difference did not reach statistical significance (p = 0.108). No significant differences were found in 90-day mortality (10.7% vs. 12.5%, p = 0.776) or long-term mortality (66.1% vs. 58.3%, p = 0.416) between the groups.

conclusionPreoperative sarcopenia is associated with a higher risk of postoperative morbidity following major hepatectomy. However, preoperative sarcopenia does not significantly affect short-term or long-term mortality. Routine assessment of muscle mass should be considered in preoperative evaluations to identify vulnerable patients and tailor perioperative management strategies.

Indexed as

HepatectomyLiver NeoplasmsPostoperative ComplicationsSarcopeniaAgedFemaleHumansMaleMiddle AgedRetrospective StudiesTomography, X-Ray ComputedLiver malignancyMajor hepatectomyPostoperative outcomesSarcopenia

Identifiers

PMID41361809
PMCPMC12781710

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.