Evidence map›Paper›PMID 41361944›Full record

ArticlePsychological medicine2025

Amygdala and insula activation in youth with avoidant/restrictive food intake disorder in response to aversive food-specific fear images.

Clara O Sailer, Francesca Galbiati, Laura M Holsen, Lilian Palmer, Avery L Van De Water, Thilo Deckersbach, Reitumetse Pulumo, Kendra K Becker, Lauren Breithaupt, Madison Fisher and 7 more

Abstract read
In one paragraph

Article in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Clara O SailerNeuroendocrine Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-6439-8191
Francesca GalbiatiNeuroendocrine Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-0744-2541
Laura M HolsenMultidisciplinary Eating Disorders Research Collaborative, Harvard Medical School, Boston, MA, USA.
Lilian PalmerNeuroendocrine Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-3608-5395
Avery L Van De WaterMultidisciplinary Eating Disorders Research Collaborative, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-3061-1964
Thilo DeckersbachUniversity of Applied Sciences, DIPLOMA Hochschule, Bad Sooden-Allendorf, Germany.ORCID 0000-0001-7643-0347
Reitumetse PulumoNeuroendocrine Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Kendra K BeckerMultidisciplinary Eating Disorders Research Collaborative, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-8946-9977
Lauren BreithauptMultidisciplinary Eating Disorders Research Collaborative, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-2439-6519
Madison FisherMultidisciplinary Eating Disorders Research Collaborative, Harvard Medical School, Boston, MA, USA.
Elisa AsanzaNeuroendocrine Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Nouchine HadjikhaniAthinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-4075-3106
Madhusmita MisraMultidisciplinary Eating Disorders Research Collaborative, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-9405-2981
Kamryn EddyMultidisciplinary Eating Disorders Research Collaborative, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-1586-0930
Nadia MicaliCenter for Eating and feeding Disorders Research, Mental Health Center Ballerup, Copenhagen University Hospital - Mental Health Services CPH, Denmark.ORCID 0000-0001-5571-2273
Elizabeth A LawsonNeuroendocrine Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8619-3349
Jennifer J ThomasMultidisciplinary Eating Disorders Research Collaborative, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-2601-581X

Funding

The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
The Role of Negative Affect in the Cognitive-Behavioral Model of Avoidant/Restrictive Food Intake Disorder: An Integrated Analysis of Neural Circuitry, Hormones, and Momentary Negative EmotionsK23MH125143 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BECKER, KENDRA R · 2021 to 2025
$1.1M
Neurobiology of avoidant/restrictive eating in youthK24MH120568 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI LAWSON, ELIZABETH AUSTEN · 2019 to 2023
$961k
Foundation for the National Institutes of Health R01MH108595National Institute of Mental Health and Neurosciences K23MH125143National Institute of Mental Health and Neurosciences K24MH135189NCATS NIH HHS UL1 TR002541NIDDK NIH HHS P30 DK040561NIMH NIH HHS K23 MH125143NIMH NIH HHS K24MH120568Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung P2BSP3_195645
6 · The paper itself

Abstract

backgroundAvoidant/restrictive food intake disorder (ARFID) leads to faltering growth and psychosocial impairment. Three phenotypes can co-occur: fear of aversive consequences of eating (

methodsYouth (N=103: 76 ARFID, including 20

resultsAcross individuals, there was a robust bilateral amygdala response to ARFID-specific fear versus neutral images. Compared to HC,

conclusionsARFID-specific fear images elicit amygdala responses across individuals, with greater activation in the insula only in

Indexed as

AmygdalaAvoidant Restrictive Food Intake DisorderCerebral CortexFearInsular CortexAdolescentChildFemaleHumansMagnetic Resonance ImagingMaleanxietyARFIDfeeding and eating disordersfood cuesneuroendocrinologyneuroimaging

Identifiers

PMID41361944
PMCPMC13058619

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.