Evidence mapPaperPMID 41362091Full record

ArticlePhysiological reports2025

Resistance to doxorubicin-induced proteinuria and proteolytic activation of ENaC in 129S2/SvPas mice.

Evan C Ray, Ivy Liu, Niloofar Momenzadeh, Kennedy Szekely, Allison L Marciszyn, Tracey Lam, Andrew J Nickerson, Thomas R Kleyman

Abstract read
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Evan C RayDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-1491-4869
Ivy LiuDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Niloofar MomenzadehDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Kennedy SzekelyDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Allison L MarciszynDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Tracey LamDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Andrew J NickersonDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Thomas R KleymanDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-2413-5415

Funding

ENaC regulation and its role in blood pressure homeostasisR01HL147818 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2022 to 2025
$2.0M
Resource Development CoreU54DK137329 · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2025 to 2025
$953k
Regulation of Renal Tubular Mg2+ Handling by MUC1 and LactationR01DK139177 · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2025 to 2025
$650k
Role of BK gamma subunits in renal K secretionK01DK140634 · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2025 to 2025
$149k
American Society of Nephrology Carl W. Gottschalk Research Scholar GrantHHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL147818HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) F32DK136356HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) K01DK140634HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK139177HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) U54DK137329NHLBI NIH HHS R01 HL147818NIDDK NIH HHS K01 DK140634NIDDK NIH HHS U54 DK137329
6 · The paper itself

Abstract

Doxorubicin treatment of mice represents a convenient model to study the effects of proteinuria on proteolytic processing of the epithelial Na

Indexed as

Antibiotics, AntineoplasticDoxorubicinEpithelial Sodium ChannelsProteinuriaAnimalsDNA-Activated Protein KinaseMaleMiceProteolysisSodiumAntibiotics, AntineoplasticDNA-Activated Protein KinaseDoxorubicinEpithelial Sodium ChannelsSodium129svadriamycinalbuminuriadoxorubicinENaCPrkdcproteinuria

Identifiers

PMID41362091
PMCPMC12686598

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.