ReviewJournal of diabetes research2025
Astragaloside IV Improves Diabetic Kidney Disease by Regulating NLRP3 Inflammasome.
Review in Journal of diabetes research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The Mechanism and Application of Traditional Chinese Medicine Nano-Formulations in the Treatment of Renal Fibrosis.International journal of nanomedicine · 2026Review
- Astragaloside IV Alleviates Lupus Nephritis by Inhibiting Podocyte Ferroptosis via the PI3K/AKT/Nrf2 Pathway.Drug design, development and therapy · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetic kidney disease (DKD) is a chronic complication that seriously affects the prognosis of diabetic patients and is a primary reason for end-stage renal disease worldwide. The existing treatment strategies have shown unsatisfactory results in the clinical practice of DKD, and there is an immediate need to discover novel and efficacious medicines. Natural products are considered to have the potential for drug design and development due to their diverse pharmacological effects. Astragaloside IV (AS-IV) has a variety of biological activities as a natural product, and existing studies have demonstrated that it can effectively delay the progression of DKD through multiple pathways. Aseptic inflammation is a key characteristic of DKD and is crucial in its pathogenesis. Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome is an essential regulator of inflammatory amplification. In this review, we focus on the mechanisms by which AS-IV improves DKD by regulating NLRP3 inflammasome activation, including anti-inflammatory, antioxidative stress, reducing endoplasmic reticulum stress (ERS), regulating lipid metabolism disorders, and reducing pyroptosis. These discoveries have provided new ideas for the treatment of DKD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.