Evidence map›Paper›PMID 41362709›Full record

ArticleJHEP reports : innovation in hepatology2025

Macrophage MRC2 deficiency mitigates HFD-induced MASLD by downregulating CD147-regulated TNF-α production.

Hui-Ru Kuo, Kwei-Yan Liu, Hsin-Ying Clair Chiou, Yu-Fen Chung, Li-Ting Wang, Chih-Wen Wang, Shih-Hsien Hsu, Shau-Ku Huang, Ming-Hong Lin

Abstract read
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In one paragraph

Article in JHEP reports : innovation in hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hui-Ru KuoGraduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Kwei-Yan LiuNational Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
Hsin-Ying Clair ChiouGenomics and Proteomics Core Laboratory, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Yu-Fen ChungNational Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
Li-Ting WangDepartment of Life Science, National Taiwan Normal University, Taipei, Taiwan.
Chih-Wen WangDepartment of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Shih-Hsien HsuGraduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Shau-Ku HuangNational Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
Ming-Hong LinGraduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background & Aims: The mechanisms underlying metabolic dysfunction-associated steatotic liver disease (MASLD) remain incompletely understood, and macrophage-associated chronic inflammation has been suggested to play a role. We investigated the potential contribution of mannose receptor type C 2 (MRC2), a transmembrane glycoprotein, to MASLD development. Methods: Wild-type (WT) and Results: MRC2 levels were significantly elevated in patients with MASLD (n = 216, Conclusions: Macrophage MRC2 promotes HFD-induced hepatic steatosis via the MRC2-CD147 complex, revealing a novel mechanism contributing to MASLD progression. Impact and implications: This study identifies the critical role of MRC2 in the development of high-fat diet-induced metabolic dysfunction-associated steatotic liver disease, providing a mechanistic understanding of its involvement in macrophage-mediated inflammation.

Indexed as

CD147Lipid metabolismMacrophageMannose receptor C type 2Metabolic dysfunction-associated steatotic liver disease

Identifiers

PMID41362709
PMCPMC12682121

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.