Evidence map›Paper›PMID 41362830›Full record

ArticleBioactive materials2026

Bioprinting of live platelet-loaded nerve conduit using energy-dissipative hydrogel.

Jiamei Zhang, Wenbi Wu, Ya Ren, Xide Dai, Shuwei Ye, Wei Zhao, Haofan Liu, Liming He, Boya Li, Li Zhang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jiamei ZhangDepartment of Biotherapy Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Wenbi WuDepartment of Biotherapy Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Ya RenDepartment of Biotherapy Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Xide DaiDepartment of Biotherapy Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Shuwei YeDepartment of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Wei ZhaoDepartment of Biotherapy Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Haofan LiuDepartment of Biotherapy Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Liming HeDepartment of Biotherapy Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Boya LiDepartment of Biotherapy Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Li ZhangDepartment of Biotherapy Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Xia LuoDepartment of Biotherapy Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Wentao LiDepartment of Biotherapy Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Xue ZhangDepartment of Biotherapy Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Shuai YangDepartment of Biotherapy Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Maling GouDepartment of Biotherapy Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Platelets show great promise for nerve repair due to their abundant release of growth factors. However, they often suffer from rapid activation-induced burst release of the cargo, making it challenging to develop long-acting platelet preparation. Here, we show a biosynthetic nerve conduit containing platelets with prolonged survival for peripheral nerve repair. This conduit was rapidly fabricated using a customized 3D printer by coating a platelet-loaded Pluronic F127 diacrylate hydrogel onto an electrospinning polycaprolactone conduit. The hydrogel can protect the platelets from stress-induced activation during deformation through its nanocolloid-based energy-dissipative centers, achieving a platelet survival rate of 34.7 % after 600 compression cycles. Platelets survived in this hydrogel for over 2 weeks, enabling the sustained release of bioactive cargo such as NGF and VEGF for more than 20 days. This conduit also had good mechanical properties, including compression and stretch resistance, to support surgical suturing and structural stability

Indexed as

BioprintingPeripheral nerve repairPlateletSustained release

Identifiers

PMID41362830
PMCPMC12682149

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.