ReviewJID innovations : skin science from molecules to population health2026
Mucosal-Associated Invariant T (MAIT) Cells in Skin Immunity: Metabolic Regulation, Tissue Adaptation, and Roles in Skin Inflammation and Disease.
Review in JID innovations : skin science from molecules to population health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Case Report: Bimekizumab for dissecting cellulitis of the scalp.Frontiers in immunology · 2026Article
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Authors and funding
5 authors.
Funding
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Abstract
Mucosal-associated invariant T (MAIT) cells are a unique subset of innate-like T lymphocytes that recognize microbial-derived vitamin B metabolites presented by the nonpolymorphic MR1 (major histocompatibility complex class I-related protein). These cells comprise about 1-10% of circulating T cells in humans and are abundant at mucosal surfaces, including the skin. MAIT cells possess a semi-invariant TCR (typically, TRAV1-2/TRAJ33 in humans) and can be activated by riboflavin metabolites such as 5-OP-RU (5-[2-oxopropylideneamino]-6-d-ribitylaminouracil) and 5-OE-RU (5-2-oxoethylideneamino]-6-d-ribitylaminouracil) as well as through cytokine-mediated pathways independent of MR1. Upon activation, MAIT cells quickly produce proinflammatory cytokines, including IFN-γ, TNF-α, and IL-17, and perform cytotoxic functions by releasing granzyme B and perforin. This review thoroughly explores the role of MAIT cells in skin immunity and skin diseases. We detail their involvement in inflammatory skin conditions such as psoriasis, atopic dermatitis, and hidradenitis suppurativa, where alterations in MAIT cell numbers and functions have been observed. The review also addresses MAIT cells' roles in wound healing, tissue repair, and antimicrobial defense within the skin. Furthermore, we evaluate the potential of targeting MAIT cells for therapy, including how current treatments affect them and the development of new immunometabolic strategies. Gaining a better understanding of MAIT cell biology in skin contexts could provide new insights into the development of skin diseases and lead to innovative dermatological treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.