Evidence map›Paper›PMID 41364150›Full record

ReviewEndocrine2025

Male hypogonadism in transition age: fertility outcomes and practical management.

M Spaziani, R Mazzilli, E Delli Paoli, F Angelini, A C Conflitti, M Martin, A Di Nisio, A Villa, F Lombardo, D Paoli and 2 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Endocrine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

M SpazianiSection of Medical Pathophysiology and Endocrinology, Department of Experimental Medicine, Sapienza University of Rome, 00161, Rome, Italy. matteo.spaziani@uniroma1.it.
R MazzilliUnit of Endocrinology, Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
E Delli PaoliLaboratory of Seminology-Sperm Bank "Loredana Gandini", Department of Experimental Medicine, "Sapienza" University of Rome, 00161, Rome, Italy.
F AngeliniSection of Medical Pathophysiology and Endocrinology, Department of Experimental Medicine, Sapienza University of Rome, 00161, Rome, Italy.
A C ConflittiLaboratory of Seminology-Sperm Bank "Loredana Gandini", Department of Experimental Medicine, "Sapienza" University of Rome, 00161, Rome, Italy.
M MartinDepartment of Medicine, Unit of Andrology and Reproductive Medicine, University of Padova, Padova, Italy.
A Di NisioDepartment of Medicine, Unit of Andrology and Reproductive Medicine, University of Padova, Padova, Italy.
A VillaSection of Medical Pathophysiology and Endocrinology, Department of Experimental Medicine, Sapienza University of Rome, 00161, Rome, Italy.
F LombardoLaboratory of Seminology-Sperm Bank "Loredana Gandini", Department of Experimental Medicine, "Sapienza" University of Rome, 00161, Rome, Italy.
D PaoliLaboratory of Seminology-Sperm Bank "Loredana Gandini", Department of Experimental Medicine, "Sapienza" University of Rome, 00161, Rome, Italy.
F PallottiFaculty of Medicine and Surgery, University of Enna "Kore", Contrada Santa Panasia, 94100, Enna, Italy.
TALENT group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe transition from childhood to adulthood represents a critical period for the onset and management of male hypogonadism. During this phase, both hypogonadotropic and hypergonadotropic forms may emerge, often presenting as delayed puberty. Early diagnosis is essential for appropriate management and fertility preservation. This review aims to provide a comprehensive overview of male hypogonadism during the transition age, focusing on its classification, clinical implications, fertility outcomes, and preservation strategies.

aimsThis review aims to synthesize current evidence on the diagnosis, clinical presentation, and management of male hypogonadism during the transition age, with a specific focus on fertility outcomes and preservation strategies across different etiologies, including both congenital and acquired forms.

conclusionsThe management of male hypogonadism during the transition age should be approached on an individual basis, with consideration given to the underlying etiology, the age of the patient, and the possibilities for fertility preservation. Fertility preservation may involve hormonal therapies or surgical techniques, such as TESE or microTESE. The choice of technique should be guided by a multidisciplinary team. It is imperative that decisions are tailored on a case-by-case basis, with due consideration given to clinical presentation and surgical expertise, in order to optimise long-term reproductive outcomes.

Indexed as

FertilityFertility PreservationHypogonadismInfertility, MaleHumansMaleFertility preservationKlinefelter syndromeMale hypogonadismPubertyTESETransition age

Identifiers

PMID41364150

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.