Evidence map›Paper›PMID 41364282›Full record

ArticlePituitary2025

Association between vertebral fracture risk and bone mineral density in patients with acromegaly.

Shuaiming Chen, Min Liu, Huiwen Tan, Lin Ji, Yerong Yu, Shu Jiang, Bowen Cai, Wei Wang, Songping Zheng, Xin Zan and 3 more

Abstract read
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In one paragraph

Article in Pituitary, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shuaiming ChenDepartment of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, China.
Min LiuDepartment of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, China.
Huiwen TanDepartment of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, China.
Lin JiDepartment of Radiology, West China Hospital of Sichuan University, Chengdu, China.
Yerong YuDepartment of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, China.
Shu JiangDepartment of Neurosurgery, West China Hospital of Sichuan University, Chengdu, China.
Bowen CaiDepartment of Neurosurgery, West China Hospital of Sichuan University, Chengdu, China.
Wei WangDepartment of Neurosurgery, West China Hospital of Sichuan University, Chengdu, China.
Songping ZhengDepartment of Neurosurgery, West China Hospital of Sichuan University, Chengdu, China.
Xin ZanDepartment of Neurosurgery, West China Hospital of Sichuan University, Chengdu, China.
Huan XuDepartment of Pathology, West China Hospital of Sichuan University, Chengdu, China.
Jing LiDepartment of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, China. lijingcd@hotmail.com.
Jianwei LiDepartment of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, China. jerryli678@hotmail.com.

Funding

Grant 1.3.5 project for Disciplines of Excellence Clinical Research Incubation Project, West China Hospital of Sichuan University 2020HXFH034
6 · The paper itself

Abstract

purposeTo investigate the prevalence and risk factors of vertebral fractures (VFs) and to compare bone mineral density (BMD) assessments by dual-energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT) in patients with acromegaly.

methodsThis cross-sectional study included 149 patients with acromegaly. Clinical, biochemical, and imaging data were collected, and logistic regression analyses were performed to identify VF risk factors.

resultsVFs were detected in 39.6% of patients and were associated with older age, longer disease duration, higher body mass index(BMI), elevated IGF-1 levels, and lower serum phosphorus. QCT-derived volumetric BMD (vBMD) was significantly lower in patients with VFs, whereas DXA-based lumbar areal BMD (aBMD) did not differ between groups. Elevated IGF-1 (%ULN) and reduced vBMD were identified as independent risk factors for VFs.

conclusionVertebral fractures are common in acromegaly. In one of the largest Chinese acromegaly cohorts to date, QCT demonstrated superior discrimination of VF risk compared with DXA, supporting its potential complementary role in skeletal fragility assessment in acromegaly.

Indexed as

Absorptiometry, PhotonAcromegalyBone DensitySpinal FracturesTomography, X-Ray ComputedAdultBody Mass IndexCross-Sectional StudiesFemaleHumansInsulin-Like Growth Factor IMaleMiddle AgedPrevalenceRisk FactorsSpineInsulin-Like Growth Factor IAcromegalyBone mineral densityDXAQCTVertebral fractures

Identifiers

PMID41364282

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.