ArticleArchives of osteoporosis2025
Distinct associations between bone mineral density and severity of white matter hyperintensities of presumed vascular origin in older men and women. The three villages study.
Article in Archives of osteoporosis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a rural cohort of older adults, osteoporosis was associated with moderate-to-severe white matter hyperintensities of presumed vascular origin in men but not women. This association was influenced by age and diet. Study results underscore potential sex-specific cerebrovascular implications of low bone mineral density.
objectivesThis study aimed to assess the association between bone mineral density (BMD) and white matter hyperintensities (WMH) of presumed vascular origin in men and women aged ≥ 60 years living in rural settings.
methodsFollowing a population-based cross-sectional design, participants received dual-energy x-ray absorptiometry to estimate bone health, and a brain MRI to grade WMH severity. Logistic regression models, adjusted for relevant confounders, were fitted to assess the association between categories of BMD (normal, osteopenia and osteoporosis), as well as the continuous BMD value, and the presence of moderate-to-severe WMH.
resultsThe study included 399 participants (mean age 68.8 ± 6.8 years; 42% men). A total of 94 (24%) individuals had normal BMD T-scores, 149 (37%) had osteopenia, and 156 (39%) had osteoporosis. Moderate-to-severe WMH were detected in 88 (22%) cases. Logistic regression models, adjusted for the above-mentioned covariates, showed no significant association between categories of BMD and WMH severity in the total population. When men and women were modeled separately, the association between osteoporosis and moderate-to-severe WMH became significant for men (OR: 7.15; 95% C.I.: 1.13 - 45.3), but not for women. Parsimonious models showed that covariates driving this association significant were the combination of age and diet (OR: 6.41; 95% C.I.: 1.04 - 39.7). Similar findings were noted when BMD was treated as a continuous variable.
conclusionOsteoporosis is associated with a higher prevalence of moderate-to-severe WMH in older men living in a population of frequent fish consumers. Increasing age and an unhealthy diet contributed significantly to this association.
Indexed as
Identifiers
41364303What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.