Evidence map›Paper›PMID 41365690›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2026

Noncanonical Taste Transduction of Sugars Elicits Responses in a Dedicated Subset of Gustatory Afferent Neurons.

Yuryanni Rodriguez, Sebastien Hayoz, Gennady Dvoryanchikov, Stephen D Roper, Nirupa Chaudhari

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuryanni RodriguezDepartments of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Florida 33136.
Sebastien HayozDepartments of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Florida 33136.
Gennady DvoryanchikovDepartments of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Florida 33136.
Stephen D RoperDepartments of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Florida 33136 sroper@med.miami.edu nchaudhari@med.miami.edu.ORCID 0000-0001-6049-8320
Nirupa ChaudhariDepartments of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Florida 33136 sroper@med.miami.edu nchaudhari@med.miami.edu.ORCID 0000-0002-3883-5893

Funding

Research Supplement to Promote Diversity in Health-Related Research-Functions of gustatory afferent neuron types.R01DC018733 · NIDCD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CHAUDHARI, NIRUPA, ROPER, STEPHEN D. · 2020 to 2025
$3.3M
Mapping gustatory neuron types.R01DC017303 · NIDCD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CHAUDHARI, NIRUPA · 2019 to 2023
$2.3M
NIDCD NIH HHS R01 DC017303NIDCD NIH HHS R01 DC018733
6 · The paper itself

Abstract

In taste buds, the GPCR heterodimer TAS1R2 + TAS1R3 is considered the canonical taste receptor for sugars and noncaloric sweeteners. Nevertheless, evidence has accumulated for the presence of an alternative noncanonical transduction pathway that detects sugars, particularly at high concentration. Sodium-glucose transporter 1 (SGLT1) has been proposed as this transducer, selectively transporting glucose into a subset of taste bud cells which then transmit the signal to taste afferent neurons. To test for TAS1R-independent sweet taste detection, we conducted in vivo Ca

Indexed as

Neurons, AfferentSignal TransductionSugarsTasteTaste BudsAnimalsFemaleGeniculate GanglionGlucoseMaleMiceMice, Inbred C57BLMice, KnockoutPhospholipase C betaReceptors, G-Protein-CoupledGlucosePhospholipase C betaPlcb2 protein, mouseReceptors, G-Protein-CoupledSugarstaste receptors, type 1Ca2+ imagingchemosensory neuronsperipheral sensory neuronssweet taste transduction

Identifiers

PMID41365690
PMCPMC12853246

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.