ArticleMovement disorders : official journal of the Movement Disorder Society2026
Longitudinal Dynamics of Plasma Neurofilament Light Chain in Hereditary Spastic Paraplegia Type 11 (HSP-SPG11) and Type 15 (HSP-ZFYVE26).
Article in Movement disorders : official journal of the Movement Disorder Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Reply to: "Mathematical Comments on Linking Neurofilament Light Chain Levels to Disease Severity in HSP Subtypes SPG11 and SPG15".Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Reply to: Mathematical Comments on Linking Neurofilament Light Chain Levels to Disease Severity in Hereditary Spastic Paraplegia Subtypes SPG11 and SPG15.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Mathematical Comments on Linking Neurofilament Light Chain Levels to Disease Severity in Hereditary Spastic Paraplegia Subtypes SPG11 and SPG15.Movement disorders : official journal of the Movement Disorder Society · 2026Article
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
backgroundHSP-SPG11 and HSP-ZFYVE26 are autosomal-recessive forms of hereditary spastic paraplegias (HSPs). As therapeutic trials emerge, validated biomarkers are critically needed.
objectivesTo evaluate plasma neurofilament light chain (pNfL) as a biomarker for neurodegeneration and disease progression.
methodsWe analyzed pNfL levels in 57 patients (36 HSP-SPG11, 21 HSP-ZFYVE26) and matched controls using single-molecule array technology. Longitudinal clinical and biomarker data were collected over 5 years.
resultsBaseline pNfL levels were significantly elevated in patients: 33.85 pg/mL (IQR 25.15-47.38) in HSP-SPG11, 46.70 pg/mL (IQR 29.95-54.84) in HSP-ZFYVE26, and 4.90 pg/mL (IQR 3.48-6.90) in controls (P < 0.001). No significant difference was observed between HSP-SPG11 and HSP-ZFYVE26. In matched pair analysis, pNfL showed inverse correlation with age (ρ = -0.463, P < 0.001). Baseline pNfL did not predict future clinical progression.
conclusionsElevated pNfL reflects early neuroaxonal injury in HSP-SPG11 and HSP-ZFYVE26; however, it could not be used as a surrogate for disease progression. © 2025 International Parkinson and Movement Disorder Society.
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