ArticleCell death & disease2025
RAB25 modulates pit cell commitment by coordinating transforming growth factor-alpha secretion from gastric epithelial cells.
Haengdueng Jeong, Yura Lee, Chanyang Uhm, Seok Young Hwang, Sumin Hur, Minsoo Noh, Robert J Coffey, James R Goldenring, Ki Taek Nam
Abstract read
In one paragraphArticle in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors.
Yura LeeDepartment of Biomedical Sciences, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.
Chanyang UhmDepartment of Biomedical Sciences, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.
Seok Young HwangNatural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, Korea.
Sumin HurDepartment of Biomedical Sciences, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.
Minsoo NohNatural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, Korea.
Robert J CoffeyEpithelial Biology Center and Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
James R GoldenringEpithelial Biology Center and Department of Surgery, Vanderbilt University Medical Center and the Nashville VA Medical Center, Nashville, TN, USA. jim.goldenring@vanderbilt.edu.ORCID http://orcid.org/0000-0002-7833-2940 Funding
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9MSMALL GTP BINDING PROTEINS IN GASTROINTESTINAL MUCOSAR01DK048370 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GOLDENRING, JAMES RICHARD · 1994 to 2025
$10.1MIntegrated approach to study early and late events in colonic neoplasia: mouse to manR35CA197570 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Robert J. Coffey · 2017 to 2026
$9.4MInduction and Evolution of Metaplasia in the StomachR01DK101332 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eunyoung Choi, James Richard Goldenring · 2014 to 2026
$5.9MHierarchy of oncogenic gene mutations in gastric carcinogenesisR01CA272687 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CHOI, EUNYOUNG, GOLDENRING, JAMES RICHARD · 2022 to 2025
$5.3MBLRD VA I01 BX000930National Research Foundation of Korea (NRF) 2022M3A9F3016364National Research Foundation of Korea (NRF) 2022R1A2C3007850National Research Foundation of Korea (NRF) 2022R1C1C2009361National Research Foundation of Korea (NRF) RS-2023-00241446National Research Foundation of Korea (NRF) RS-2024-00400118National Research Foundation of Korea (NRF) RS-2024-00407093NCI NIH HHS R01 CA272687NCI NIH HHS R35 CA197570NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK048370NIDDK NIH HHS R01 DK101332U.S. Department of Defense (United States Department of Defense) CA190172U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01 DK48370U.S. Department of Veterans Affairs (Department of Veterans Affairs) IBX000930
6 · The paper itselfAbstract
EGFR signaling serves as a regulator of lineage commitment in the stomach. A recent study revealed that two different EGFR ligands can induce fate determination of isthmus progenitors in corpus, but the source and regulatory mechanism of the ligands remain unclear. We analyzed single-cell RNA sequencing and found that Rab25 was strongly expressed in epithelial cells in upper corpus glands along with transforming growth factor-alpha (TGFA) associated with pit lineage commitment. Using mouse primary cell culture, we found that Rab25 loss facilitated TGFA secretion and subsequently promoted upregulation of EGFR signaling in the pit region. Long-term alteration of TGFA secretion in Rab25 KO mice caused gastric lesions with massive foveolar hyperplasia. Most importantly, this corpus lesion was ameliorated by neutralization of TGFA. Moreover, RAB25 expression was reduced in human Ménétrier's disease. Collectively, we provide evidence for a physiological role of Rab25 in the gastric environment to maintain normal lineage commitment.
Indexed as
Epithelial CellsGastric Mucosarab GTP-Binding ProteinsTransforming Growth Factor alphaAnimalsCell LineageErbB ReceptorsGastritis, HypertrophicHumansMiceMice, Inbred C57BLMice, KnockoutSignal TransductionErbB ReceptorsRab25 protein, humanrab GTP-Binding ProteinsTransforming Growth Factor alpha
Identifiers
PMID41365858
PMCPMC12824383
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390