Evidence map›Paper›PMID 41365877›Full record

ArticleNature communications2025

Biguanide-functionalized peptide mimics effectively combat drug-resistant ESKAPE pathogens and meningitis.

Weinan Jiang, Min Zhou, Kang Chen, Ximian Xiao, Jia Shi, Haodong Zhang, Jiayang Xie, Sheng Chen, Minzhang Chen, Zihao Cong and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Weinan JiangSuzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, China.
Min ZhouState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.ORCID http://orcid.org/0000-0002-0444-0324
Kang ChenState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Ximian XiaoState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.ORCID http://orcid.org/0000-0002-7096-8784
Jia ShiState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Haodong ZhangState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.ORCID http://orcid.org/0000-0002-1186-8732
Jiayang XieSuzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, China.
Sheng ChenState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.ORCID http://orcid.org/0000-0001-9090-3905
Minzhang ChenState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Zihao CongState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.ORCID http://orcid.org/0000-0003-3462-7373
Longqiang LiuState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Yueming WuState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China. yuemingwu@ecust.edu.cn.ORCID http://orcid.org/0000-0001-7668-7409
Runhui LiuSuzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, China. rliu@ecust.edu.cn.ORCID http://orcid.org/0000-0002-7699-086X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ESKAPE pathogens-induced meningitis seriously threatens human health due to antimicrobial resistance and low permeability of blood-brain barrier (BBB). It's a promising strategy to combat drug-resistant pathogens using synthetic mimics of host defense peptide (HDP) bearing positive charges that are mainly provided by amine or guanidine. Here, we report that biguanide serves as a type of positively charged moiety to design HDP mimics. Biguanide exerts a stronger interaction with bacterial membrane phospholipids via bidentate hydrogen bonds than do amine and guanidine. The biguanide-functionalized HDP mimic, PBGProOx

Indexed as

Anti-Bacterial AgentsAntimicrobial Cationic PeptidesBiguanidesMeningitis, BacterialAnimalsBlood-Brain BarrierDisease Models, AnimalDrug Resistance, BacterialFemaleHumansMiceMicrobial Sensitivity TestsAnti-Bacterial AgentsAntimicrobial Cationic PeptidesBiguanides

Identifiers

PMID41365877
PMCPMC12789443

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.