ArticleCommunications biology2025
Revealing the light-regulated circadian rhythm in the vector mosquitoes, Aedes albopictus and Culex quinquefasciatus.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Behavioral determinants of disease transmission by mosquitoes.Current opinion in insect science · 2026Review
- The circadian clock gene CYCLE as a potential target for disrupting blood-feeding behavior in the mosquito Culex pipiens.PLoS neglected tropical diseases · 2026Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
Light serves as a primary zeitgeber for regulating circadian rhythms in mosquitoes. As important vector insects, the diurnal Aedes albopictus and the nocturnal Culex quinquefasciatus are not only nuisance biters, but also transmit viruses such as dengue, Zika, and West Nile. We conducted a comparative analysis of the oscillating molecular rhythms in these two mosquito species. Light-blocking paint application experiments reveal species-specific photic pathways. CRISPR/Cas9 knockouts of the Aalopsin1, Cxqopsin6, and Cry1 genes revealed that Ae. albopictus relies principally on the compound eye pathway, whereas Cx. quinquefasciatus depends more on the non-visual ocelli-like pathway for circadian rhythm regulation. In addition, different light conditions can affect the lifespan of adult mosquitoes. These findings reveal the light-regulated circadian rhythm in diurnal and nocturnal vector mosquitoes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.