ArticleNature metabolism2025
Dietary restriction reprograms CD8
Abstract read
In one paragraph
Article in Nature metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Immunometabolic Effects of SGLT2 Inhibitors on the Th17/Treg Axis: Mechanisms, Evidence, and Implications for Therapeutic Repurposing.Molecular biology reports · 2026Review
- Article
- Endogenous metabolite signaling orchestrates tumor immune evasion.Cell insight · 2026Review
- Metabolic Signaling Meets Epigenetic Regulation: How Protein Lactylation Remodels the Tumor Immune Microenvironment in Gastric Cancer.Current issues in molecular biology · 2026Review
- Glucose restriction reprograms lipid metabolism and enhances immunotherapy through ZNRF3-Wnt-SCD signaling axis.Journal for immunotherapy of cancer · 2026Article
- Hyperglycosylation is a metabolic driver of Alzheimer's disease.Nature metabolism · 2026Article
- Metabolic Crosstalk Between Host and Tumor as a Circuit of Resilience in Cancer Therapy.Cells · 2026Review
- β-hydroxybutyrate potentiates anti-tumor immunity by modulating cytotoxic CD8Cancer immunology, immunotherapy : CII · 2026Article
- Revealing key genes and molecular mechanisms associated with dietary restriction in ulcerative colitis.Frontiers in molecular biosciences · 2026Article
- How the Ketogenic Diet Shapes the Microbiome to Influence Cancer Immunotherapy Outcomes: An Exploration of Clinical Trials and Their Results.Nutrition and cancer · 2026Review
- Targeting immunometabolism in cancer through pharmacological and lifestyle interventions.PLoS biology · 2026Review
Corrections and comments
- Update of
Authors and funding
23 authors.
Brandon M OswaldDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Lisa M DeCampDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Joseph LongoDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.ORCID http://orcid.org/0000-0002-9580-5105
Michael S DahabiehDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Nicholas BundaDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Benjamin K JohnsonDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA.
McLane J WatsonDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.ORCID http://orcid.org/0000-0001-5778-7690
Shixin MaSalk Institute, La Jolla, CA, USA.
Samuel E J PrestonDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.ORCID http://orcid.org/0000-0002-2618-8326
Ryan D SheldonMass Spectrometry Core, Van Andel Institute, Grand Rapids, MI, USA.ORCID http://orcid.org/0000-0002-1573-9719
Michael P VincentMass Spectrometry Core, Van Andel Institute, Grand Rapids, MI, USA.
Abigail E EllisMass Spectrometry Core, Van Andel Institute, Grand Rapids, MI, USA.ORCID http://orcid.org/0000-0002-8736-8283
Molly T Soper-HopperMass Spectrometry Core, Van Andel Institute, Grand Rapids, MI, USA.ORCID http://orcid.org/0000-0003-2745-1680
Christine IsaguirreMass Spectrometry Core, Van Andel Institute, Grand Rapids, MI, USA.
Dahlya KamarudinDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Hui ShenDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA.ORCID http://orcid.org/0000-0001-9767-4084
Kelsey S WilliamsDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.ORCID http://orcid.org/0000-0002-4163-5075
Peter A CrawfordDepartment of Medicine, Division of Molecular Medicine, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0001-8597-4426
Susan KaechSalk Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-1674-1420
H Josh JangDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA.ORCID http://orcid.org/0000-0001-9654-4448
Evan C LienDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.ORCID http://orcid.org/0000-0001-7866-4761
Connie M KrawczykDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.ORCID http://orcid.org/0000-0002-2468-5986
Russell G JonesDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA. russell.jones@vai.org.ORCID http://orcid.org/0000-0003-2250-4675
Funding
Ketone Body Metabolism in CD8+ T Cell ResponsesR01AI165722 · VAN ANDEL RESEARCH INSTITUTE · 2025 to 2025
$1.3MDietary regulation of anti-tumor immunity through caloric restrictionU01CA297713 · VAN ANDEL RESEARCH INSTITUTE · 2025 to 2025
$767kCancer Epigenetics Training (CET) ProgramT32CA251066 · VAN ANDEL RESEARCH INSTITUTE · 2025 to 2025
$495kDamon Runyon Cancer Research Foundation (Cancer Research Fund of the Damon Runyon-Walter Winchell Foundation) DRG 2495-23Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) MFE-181903NCI NIH HHS T32 CA251066NCI NIH HHS U01 CA297713NIAID NIH HHS R01 AI165722U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) U01CA297713U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI165722
Abstract
Reducing calorie intake through dietary restriction (DR) slows tumour growth in mammals, yet the underlying mechanisms are poorly defined. Here, we show that DR enhances anti-tumour immunity by optimizing CD8
Indexed as
Caloric RestrictionCD8-Positive T-LymphocytesImmunotherapyNeoplasms3-Hydroxybutyric AcidAnimalsCell Line, TumorHumansKetone BodiesMiceMice, Inbred C57BLMitochondriaTumor Microenvironment3-Hydroxybutyric AcidKetone Bodies
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.