Evidence map›Paper›PMID 41366314›Full record

ArticleBMC geriatrics2025

Hospitalizations for cardiovascular events and risk for all cause and cardiovascular mortality in elderly patients with atrial fibrillation treated with oral anticoagulants: beyond preventing thromboembolism.

Matteo Candeloro, Qiaosen Chen, Hanne Ehrlinder, Bruna Gigante

Abstract read
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Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Matteo CandeloroDepartment of Innovative Technologies in Medicine and Dentistry, "G. D'Annunzio" University, Chieti, Italy.
Qiaosen ChenDepartment of Medicine Solna, Division of Cardiology, Karolinska Institutet, Solnavägen 30, Stockholm, 171 64, Sweden.
Hanne EhrlinderDepartment of Clinical Sciences, Division of Cardiovascular Medicine, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden.
Bruna GiganteDepartment of Medicine Solna, Division of Cardiology, Karolinska Institutet, Solnavägen 30, Stockholm, 171 64, Sweden. bruna.gigante@ki.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundElderly patients with atrial fibrillation (AF) are at increased risk of death, despite oral anticoagulant (OAC) treatment. We estimated the risk of all cause and cardiovascular (CV) death associated with hospitalizations for cardiovascular events (CVEs).

settingRetrospective cohort study.

methodsOAC treated patients (≥ 75 years) (n = 2161) discharged from a Swedish cardiology clinic with AF or atrial flutter (AFL) as main diagnosis between 2010 and 2017, were followed up for 12 months. Hospitalizations for CVEs were recorded from the national patient registry and diagnoses combined in five groups: heart failure (HF); stroke/ transient ischemic attack (TIA)/systemic embolism (SE); acute myocardial infarction and peripheral artery disease; bleeding; and other CVEs. We estimated the risk, expressed as hazard ratio (HR) and 95% confidence interval (CI) for all-cause and CV death in each hospitalization group by time-varying Cox regression.

resultsDuring 12 months of follow up, 178 patients died and 92 were CV deaths. Overall, 391 (18.5%) patients experienced a total of 490 hospitalizations for CVEs. Hospitalizations for any CVEs associated with increased risk (from 3 to 17 folds) for all-cause mortality. Risk for CV mortality increased in patients hospitalized for HF within 90 days (HR and 95%CI) 33.64 (15.97-70.89), for stroke/TIA/SE 14.73 (7.60-28.58) and for other CVEs 8.98 (4.29-18.78).

conclusionsHospitalizations for CVEs in elderly AF/AFL OAC treated patients increased the risk for all cause and CV mortality within 12 months from admission for AF/AFL. Hospitalization for HF bared the highest risk, but the residual stroke/TIA/SE risk was noteworthy.

Indexed as

AnticoagulantsAtrial FibrillationCardiovascular DiseasesHospitalizationThromboembolismAdministration, OralAgedAged, 80 and overCause of DeathCohort StudiesFemaleFollow-Up StudiesHumansMaleRegistriesRetrospective StudiesAnticoagulantsAgeingAnticoagulant treatmentAtrial fibrillationHeart failureIschemic stroke

Identifiers

PMID41366314
PMCPMC12687549

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.