ArticleLipids in health and disease2025
Association of insulin resistance indices with outcomes after endovascular treatment in acute basilar artery occlusion.
Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- The C-Reactive Protein-Triglyceride-Glucose Index and Functional Outcomes in Acute Ischemic Stroke Patients Following Endovascular Thrombectomy.Brain and behavior · 2026Article
- Association of the Triglyceride-Glucose (TyG) Index and TyG-BMI With 1-Year Outcomes Following Endovascular Treatment in Acute Basilar Artery Occlusion.CNS neuroscience & therapeutics · 2026Article
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11 authors.
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Abstract
backgroundAcute basilar artery occlusion (BAO) represents an uncommon but highly devastating form of ischemic stroke, frequently resulting in severe disability or death, despite advances in endovascular treatment (EVT). Although insulin resistance (IR) has been connected to poorer neurological outcomes after stroke, evidence regarding the predictive usefulness of non-insulin-based IR indices in BAO patients receiving EVT is still limited.
methodsIn this study, 266 BAO patients who received EVT between 2012 and 2024 were analyzed. Three IR indices were calculated at admission: the triglyceride-glucose (TyG) index, the metabolic score for insulin resistance (METS-IR), and the ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL-C). The primary endpoint included a 90-day unfavorable outcome (modified Rankin scale score: 4-6), and the secondary endpoints included mortality and symptomatic intracranial hemorrhage (sICH). Associations were examined by using multivariable regression, and discriminative ability was quantified via receiver operating characteristic analysis.
resultsIn 266 patients, 149 (56.0%) demonstrated unfavorable outcomes, and 77 (28.9%) died within 90 days. Higher TyG values showed a robust association with unfavorable outcomes, mortality, and sICH; moreover, it provided the strongest predictive ability for functional outcomes (area under the curve comparisons, P < 0.05). METS-IR was associated with mortality and demonstrated a predictive ability comparable to that of TyG but weaker for functional outcome. TG/HDL-C was not significantly related to any outcome.
conclusionsAmong BAO patients who underwent EVT, the TyG index could strongly predict unfavorable functional recovery and mortality, whereas the METS-IR was mainly associated with mortality. These findings indicate that TyG may help in refining risk stratification after EVT, whereas METS-IR appears to be less informative.
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