ReviewCell communication and signaling : CCS2025
The cellular senescence-metabolism axis: emerging insights into T cell dynamics in the context of biological aging.
Review in Cell communication and signaling : CCS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The exponential growth of immunometabolism-related studies in the last 10 years has made it very clear that metabolism is a key player in the effector functions of immune cells. Such is the case in cells with lymphoid origin, as CD4 + and CD8 + T cells undergo a series of metabolic reprogramming steps during their differentiation process, which is associated with a change in their effector characteristics. Only recently have factors such as biological aging and cellular senescence been examined in relation to memory T-cell generation and the metabolic reprogramming that accompanies their differentiation. In this review, we examine the emerging roles of cellular senescence and biological aging in shaping T-cell metabolism and immune function, and how these changes in the T-cell landscape contribute to disease onset. We then discuss recent studies on T-cell metabolic reprogramming to highlight how understanding the impact of senescence on T-cell metabolism may reveal new therapeutic opportunities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.