ArticleChild and adolescent psychiatry and mental health2025
Recurrent non-suicidal self-injury in depressed youth with mixed features: a 6-month prospective cohort study.
Article in Child and adolescent psychiatry and mental health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Sex-specific diagnostic trajectories and time to transition from non-SMI to severe mental illness in Chinese adolescent inpatients.Frontiers in psychiatry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectiveThis study aimed to examine whether mixed features during a current major depressive episode (MDE) are associated with increased risk of non-suicidal self-injury (NSSI) among adolescents and young adults, focusing on both first-onset and recurrent NSSI during a 6-month follow-up period.
methodA total of 713 individuals aged 13-25 years with current MDE were recruited, including 233 with mixed features. NSSI was assessed at baseline and at 1-, 3-, and 6-month follow-ups. Multiple imputation was used to handle missing data (n = 626). Kaplan-Meier and Nelson-Aalen estimators were applied to visualize time-to-event and cumulative risk curves. Cox regression assessed first-onset NSSI, and Andersen-Gill models estimated the risk of repeated events. Rubin's rules were used to pool estimates across imputed datasets. Sensitivity analyses were performed using complete-case data after multiple imputation, while subgroup analyses were conducted using stratified models.
resultsParticipants with mixed features were more likely to be female and to report a shorter illness duration and aggression history. Mixed features were associated with earlier NSSI onset (p = .010) and higher cumulative risk (p < .001). Although no significant association was found with first-onset NSSI, mixed features significantly predicted recurrent NSSI in both imputed (HR = 1.35, p = .045) and complete-case models (HR = 1.58, p < .001). The effect was stronger among first-episode cases and those with illness duration < 6 months.
conclusionMixed features in adolescent and young adult MDE may serve as a predictor of recurrent NSSI. Early identification and tailored monitoring strategies are warranted to reduce self-injury risk.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.