Evidence map›Paper›PMID 41366546›Full record

ArticleScientific reports2025

Platelets in angiogenesis and pulmonary progenitor cell homing under chronic intermittent hypoxia.

Ayşe Demirci Şahin, Emel Güneş, Göktuğ Ömercioğlu, Ayşe Hande Yozgat, Deniz Billur, Metin Baştuğ

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ayşe Demirci ŞahinDepartment of Physiology, Ankara University Faculty of Medicine, Ankara, Turkey. aysedemirc@yahoo.com.ORCID http://orcid.org/0000-0003-0667-8886
Emel GüneşDepartment of Physiology, Ankara University Faculty of Medicine, Ankara, Turkey.ORCID http://orcid.org/0000-0003-3599-5151
Göktuğ ÖmercioğluDepartment of Physiology, Ankara University Faculty of Medicine, Ankara, Turkey.ORCID http://orcid.org/0000-0002-4387-4598
Ayşe Hande YozgatDepartment of Histology and Embryology, Ankara University Faculty of Medicine, Ankara, Turkey.ORCID http://orcid.org/0009-0002-9580-7685
Deniz BillurDepartment of Histology and Embryology, Ankara University Faculty of Medicine, Ankara, Turkey.ORCID http://orcid.org/0000-0001-8541-8251
Metin BaştuğDepartment of Physiology, Ankara University Faculty of Medicine, Ankara, Turkey.ORCID http://orcid.org/0000-0002-8008-6515

Funding

Ankara University Scientific Research Projects Coordinatorship 22L0230002
6 · The paper itself

Abstract

Platelets play a critical role in tissue repair and contain various molecules that regulate angiogenesis, such as stromal cell-derived factor-1 (SDF-1) which stimulates endothelial progenitor cells (EPCs). Chronic intermittent hypoxia (CIH) alters platelet function, but its specific impact on platelet-derived angiogenic factors and endothelial progenitor cell (EPC) recruitment in lung injury remains unclear. This study investigated the effects of CIH on the profile of pro- and anti-angiogenic molecules in platelets and their role in EPC homing during acute lung injury (ALI). Ten-week-old 35 rats were divided into control, ALI, CIH and CIH + ALI groups. CIH was applied for 6 h per day over 42 days, simulating an altitude of 3,000 m., approximately 14% O

Indexed as

Acute Lung InjuryBlood PlateletsEndothelial Progenitor CellsHypoxiaLungNeovascularization, PhysiologicAngiogenesisAnimalsCell MovementChemokine CXCL12MalePlatelet-Derived Growth FactorRatsRats, Sprague-DawleyVascular Endothelial Growth Factor AChemokine CXCL12Platelet-Derived Growth FactorVascular Endothelial Growth Factor AAcute lung injuryAngiogenesisEndothelial progenitor cellsIntermittent hypoxiaPlateletSDF-1

Identifiers

PMID41366546
PMCPMC12800019

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.