Evidence map›Paper›PMID 41366586›Full record

SynthesisCurrent nutrition reports2025

Effects of Exercise or Diet or Combined Interventions on Treatment Efficacy of Chemotherapy for Cancer: A Systematic Review.

Cristina Crespo-Garcia, Francesco Bettariga, Dennis R Taaffe, Carolyn J Peddle-McIntyre, John P Campbell, Emily Jeffery, Anna Maria Markarian, Anita Borsati, Alice Avancini, Sara Pilotto and 2 more

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Current nutrition reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Cristina Crespo-GarciaExercise Medicine Research Institute, Edith Cowan University, Perth, WA, Australia. c.crespogarcia@ecu.edu.au.ORCID http://orcid.org/0009-0004-8981-3610
Francesco BettarigaExercise Medicine Research Institute, Edith Cowan University, Perth, WA, Australia.
Dennis R TaaffeExercise Medicine Research Institute, Edith Cowan University, Perth, WA, Australia.
Carolyn J Peddle-McIntyreExercise Medicine Research Institute, Edith Cowan University, Perth, WA, Australia.
John P CampbellDepartment for Health, University of Bath, Bath, UK.
Emily JefferyCurtin School of Population Health, Curtin University, Perth, WA, Australia.
Anna Maria MarkarianExercise Medicine Research Institute, Edith Cowan University, Perth, WA, Australia.
Anita BorsatiBiomedical, Clinical and Experimental Sciences, Department of Medicine, University of Verona, Verona, Italy.
Alice AvanciniDepartment of Neurosciences, Biomedicine and Movement, University of Verona, Verona, Italy.
Sara PilottoSection of Innovation Biomedicine-Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and University and Hospital Trust (AOUI) of Verona, Verona, Italy.
Daniel A GalvaoExercise Medicine Research Institute, Edith Cowan University, Perth, WA, Australia.
Robert U NewtonExercise Medicine Research Institute, Edith Cowan University, Perth, WA, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewWhile exercise and dietary interventions in patients with cancer undergoing chemotherapy have been demonstrated to be safe and feasible and improve patient-reported outcomes, the effects on treatment efficacy have not been widely examined and remain unclear. This review aimed to examine the effects of exercise, dietary, and combined interventions on tumour response and time-to-event outcomes in patients with cancer undergoing chemotherapy. RECENT

findingsA systematic review of intervention studies was conducted based on PRISMA guidelines Databases searched were PubMed, Medline, CINAHL, Embase, and Web of Science. Methodological quality and risk of bias were assessed using the RoB2 and ROBINS-I tools. A total of 21 studies, involving 1,384 cancer patients, were included. Exercise interventions were studied in 13 studies, nine of which were controlled. Two studies reported improvements in tumour response, although none demonstrated a significant impact on survival outcomes. Dietary interventions were investigated in seven studies, all of which used either ketogenic diets or fasting-mimicking diets; three of these studies were controlled and recruited patients with breast cancer. Among all studies, three showed significant increases in tumour response and survival outcomes. Finally, only one study evaluated the combined effects of exercise and diet, reporting a significant increase in pathological complete response rates in the intervention group. Exercise and dietary interventions, particularly ketogenic and fasting-mimicking diets, may enhance tumour response and survival during chemotherapy in some cases. However, the current evidence is limited and inconsistent. Well-designed randomized controlled trials are needed to better establish the efficacy of these interventions as adjuncts to chemotherapy.

Indexed as

Antineoplastic AgentsDietExerciseExercise TherapyNeoplasmsDiet, KetogenicFemaleHumansTreatment OutcomeAntineoplastic AgentsChemotherapyDietExerciseSurvivalTumour response

Identifiers

PMID41366586

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.