Evidence map›Paper›PMID 41366616›Full record

GuidelineHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2026

Cardiovascular Prevention in Children, Adolescents, and Young Adults. A Call-to-Action of the Italian Societies of Pediatrics (SIP), Hypertension (SIIA), Study of Atherosclerosis (SISA), and Cardiovascular Prevention (SIPREC).

Simonetta Genovesi, Roberto Volpe, Davide Agnoletti, Simonetta Bellone, Gianni Bona, Manuela Casula, Luigi Gentile, Francesca Saladini, Rino Agostiniani, Agostino Virdis and 3 more

Abstract readPractice GuidelineReview
PubMed Full text at PMC Publisher
In one paragraph

Guideline in High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Simonetta GenovesiSchool of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy. simonetta.genovesi@unimib.it.ORCID http://orcid.org/0000-0002-4699-4149
Roberto VolpeHealth and Safety Unit (SPP), National Research Council (CNR), Piazzale Aldo Moro, 7, 00185, Roma, Italy.
Davide AgnolettiDepartment of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
Simonetta BelloneDivision of Pediatrics, Department of Health Sciences, Università del Piemonte Orientale, Novara, Italy.
Gianni BonaDivision of Pediatrics, Department of Health Sciences, Università del Piemonte Orientale, Novara, Italy.
Manuela CasulaIRCCS MultiMedica, Sesto San Giovanni, Milan, Italy.
Luigi GentileDiabetic Clinic, Hospital of Asti, Asti, Italy.
Francesca SaladiniCardiology Unit, Città della Town Hospital, Padova, Italy.
Rino AgostinianiDepartment of Pediatrics, San Jacopo Hospital, Pistoia, Italy.
Agostino VirdisDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Alberico L CatapanoIRCCS MultiMedica, Sesto San Giovanni, Milan, Italy.
Massimo VolpeClinical and Molecular Medicine Department, Sapienza University of Rome, Rome, Italy.
Marco GiussaniIstituto Auxologico Italiano IRCCS, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular and cerebrovascular diseases (CVDs), primarily driven by atherosclerosis, remain the leading cause of mortality worldwide and represent a major healthcare burden. Mounting evidence demonstrates that atherosclerotic processes begin in childhood, with lipid streaks detectable as early as the first decade of life. The increasing prevalence of obesity, hypertension, dyslipidemia, insulin resistance, and other modifiable cardiovascular risk factors (CVRFs) in children and adolescents highlights the urgent need for prevention strategies starting early in life. This document, jointly produced by the Italian Society of Pediatrics (SIP), the Italian Society of Hypertension (SIIA), the Italian Society for the Study of Atherosclerosis (SISA), and the Italian Society for Cardiovascular Prevention (SIPREC), emphasizes that atherosclerosis should be considered a disease with its roots in childhood and that true primary prevention must begin from pregnancy and birth. Two possible and complementary levels of intervention should be considered: (1) population-wide promotion of healthy diets, lifestyles, and supportive environments; and (2) early identification and management of specific CVRFs in children and adolescents. The involvement of multiple stakeholders-families, pediatricians, schools, healthcare professionals, policymakers, patient associations, and the media-is crucial to ensure the effectiveness of prevention interventions. Particular attention must be given to obesity, as both an independent risk factor and a driver of additional metabolic and vascular risks. Fighting CVDs requires a paradigm shift: preventive action must start early, be comprehensive, and mobilize all sectors of society. Only by addressing cardiovascular risk during childhood can the future burden of CVDs be effectively reduced.

Indexed as

Cardiovascular DiseasesPrimary PreventionRisk Reduction BehaviorAdolescentAge FactorsChildConsensusDiet, HealthyFemaleHealthy LifestyleHeart Disease Risk FactorsHumansHypertensionItalyMaleProtective FactorsAtherosclerosisCardiovascular preventionCardiovascular risk factorsPediatric health

Identifiers

PMID41366616
PMCPMC12988895

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.