Trial reportBMC anesthesiology2025
Impact of desflurane versus isoflurane on early cognitive function of the elderly undergoing lumbar surgery: a randomized clinical trial.
Trial report in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06387836 (Impact of Desflurane Versus Isoflurane on Early Cognitive Function of the Elderly Undergoing Lumbar Surgery), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Desflurane Versus Isoflurane on Early Cognitive Function of the Elderly Undergoing Lumbar Surgery: A Randomized Clinical Trial
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundIt is unclear whether desflurane, one of the most-used volatile anesthetics in clinical practice, is less likely to induce postoperative cognitive dysfunction (POCD). We here compared early postoperative cognitive function of the isoflurane and desflurane patients and explored the diagnostic performance of relative level of LINC01844 in peripheral blood for POCD.
methodsEighty-five patients underwent lumbar surgery under general anesthesia were included in the study according to inclusion and exclusion criteria. Patients were randomly allocated to either isoflurane (I) or desflurane (D) study arms. A battery of 7-item neurocognitive tests was performed repeatedly on one day preoperatively and 1st, 3rd and 5th day postoperatively (POD1,3,5) and peripheral blood samples were drawn simultaneously. POCD was diagnosed using the Z-score method. The relative level of LINC01844 was decided by quantitative real-time polymerase chain reaction. The primary outcome was the incidence of POCD within 5 days postoperatively. Binary logistic regression analysis and receiver operating characteristic (ROC) curves were used for the analysis of diagnostic performance of LINC01844 level for POCD.
resultsThe incidence of POCD within 5 days postoperatively was significantly lower in D group than in the I group (p = 0.001). Compared to I group, LINC01844 relative levels in D group were significantly lower on POD1(p < 0.001), POD3(p = 0.003) and POD5(p < 0.001). Patients diagnosed with POCD had higher LINC01844 relative level on POD1(p < 0.001), POD3(p = 0.003) and POD5(p < 0.001). Binary logistic regression analysis found that POCD was independently associated with LINC01844 relative level of POD1, POD3 and POD5(OR 14.862, 95%CI 3.735-29.136, p<0.001; OR 2.383, 95%CI 1.506-3.769, p<0.001; OR 3.469, 95%CI 1.744-6.902, p<0.001, respectively). The ROC curves showed that the areas under the curve for LINC01844 relative levels on POD1, POD3 and POD5 were 0.946(95%CI: 0.900-0.992, p<0.001), 0.795(95%CI: 0.675-0.915, p<0.001) and 0.769(95%CI: 0.654-0.885, p<0.001), respectively.
conclusionDesflurane had less impact on postoperative cognitive function of the elderly patients and had less interference with expression of LINC01844. The relative level of LINC01844 in peripheral blood may be a potential biomarker for POCD.
trial registrationRegistered with ClinicalTrials.gov (NCT06387836, principal investigator: Shengjin Ge; April 2024).
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.