ArticleMedicine2025
Unraveling the causal landscape of intervertebral disc degeneration: A Mendelian randomization analysis of 108 traits.
Article in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intervertebral disc degeneration (IVDD) is a main contributor to low back pain, often considered a chronic condition. This highlights the importance of early identification of potential risk factors and implementation of preventive measures. Therefore, comprehending the causal factors underlying IVDD is crucial. We employed independent genetic variants from 108 traits as instrumental variables to analyze the causal relationships between these factors and IVDD risk. Several tests for heterogeneity and pleiotropy confirmed the validity of the data. Inverse-variance weighted model results indicated that fat distribution-related indicators were significantly positively associated with IVDD, such as "basal metabolic rate" (odds ratios [OR] = 1.49; 95% confidence interval [CI] = 1.36-1.63); "body fat percentage" (OR = 1.37; 95% CI = 1.22-1.53); "body mass index" (OR = 1.29; 95% CI = 1.21-1.38); "hip circumference" (OR = 1.24; 95% CI = 1.14-1.33), and "trunk fat mass" (OR = 1.27; 95% CI = 1.17-1.37). Additionally, there was a negative causal relationship between usual walking pace (OR = 0.45; 95% CI = 0.26-0.76) and IVDD. Maintaining a healthy weight, reducing body fat, and engaging in regular physical activity such as frequent walking may help prevent or delay the onset of IVDD in individuals who are susceptible to the condition.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.