ArticleMedicine2025
Association between weekly sleep duration and gallstones in a US-based adult sample: A cross-sectional study.
Article in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Sleep disorders and gallstone disease represent significant public health concerns, yet their potential association remains poorly understood. In particular, the association between weekly sleep duration and gallstone risk in adults has not been thoroughly investigated. Data from the National Health and Nutrition Examination Survey (NHANES, 2021-2023) were analyzed in a cross-sectional study examining weekly sleep duration and gallstone risk. Advanced multivariate regression models were employed to comprehensively analyze and adjust for potential confounders. To ensure robustness, smooth curve fitting and a three-piece threshold effect analysis were performed. Additionally, stratified analyses by gender and hypercholesterolemia status were conducted to explore potential subgroup differences. The study included 3897 adult participants with a gallstone prevalence of 6.04%. After full adjustment for potential confounders, weekly sleep duration showed a significant inverse association with gallstone risk (adjusted OR = 0.961, 95% CI: 0.942-0.981). Subgroup analyses by gender and hypercholesterolemia status consistently revealed this negative association. Notably, smooth curve fitting and threshold effect analysis demonstrated a distinct segmented relationship between weekly sleep duration and gallstone risk. Our study reveals a significant inverse correlation between weekly sleep duration and gallstone prevalence among U.S. adults, with particularly pronounced associations observed in males and individuals with hypercholesterolemia.
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