ArticleAnimal models and experimental medicine2026
Optimizing the dengue virus infection mouse model: Comparing different backgrounds and infection route for enhanced stability.
Article in Animal models and experimental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Optimizing the dengue virus infection mouse model: Comparing different backgrounds and infection route for enhanced stability.Animal models and experimental medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundIn recent decades, the global incidence of dengue fever has been steadily increasing, with continuous geographical expansion. Researchers have successfully modeled most clinical symptoms of human dengue fever using interferon type I (IFN-I) or combined IFN-I/II receptor knockout mice infected with dengue virus (DENV). However, this model requires further optimization to better support related studies.
methodsThis study aimed to establish a stable dengue infection model by evaluating the effects of different genetic backgrounds and injection routes on DENV infection in interferon receptor knockout mice. We first infected various strains of interferon receptor-deficient mice with DENV and compared their susceptibility based on clinical symptoms, viremia levels, organ indices, histopathological findings, and vascular leakage markers. Subsequently, we selected the most susceptible strain to further investigate the impact of different injection methods on infection outcomes.
resultsWe found that BALB/c background mice with type 1 interferon receptor knockout(IFNAR) had the most obvious symptoms. Subsequently, we selected IFNAR-/-BALB/c mice to further explore the effects of different injection methods on dengue virus infection. The results showed that the intraperitoneal injection group had the most severe clinical symptoms, the longest duration of viremia, and the most obvious degree of organ damage.
conclusionThrough systematic screening and optimization, we established a robust animal model of dengue virus infection via intraperitoneal injection in IFNAR-/- BALB/c mice. This model offers a valuable tool for future dengue research.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.